1151995-69-5

Basic information

• Product Name: Tubulin Polymerization Inhibitor II
• Synonyms: Tubulin Polymerization Inhibitor II
• CAS NO: 1151995-69-5
• Molecular Formula: C19H19NO5
• Molecular Weight: 341.35786
• EINECS: -0
• Product Categories: Angiogenesis and Metastasis;Growth Factors and Cytokines
• Mol File: 1151995-69-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 549.5±50.0 °C(Predicted)
• Appearance: /
• Density: 1.241±0.06 g/cm3(Predicted)
• Storage Temp.: +2C to +8C
• PKA: 12.16±0.20(Predicted)
• CAS DataBase Reference: Tubulin Polymerization Inhibitor II(CAS DataBase Reference)
• NIST Chemistry Reference: Tubulin Polymerization Inhibitor II(1151995-69-5)
• EPA Substance Registry System: Tubulin Polymerization Inhibitor II(1151995-69-5)

Safety Data

• Hazardous Substances Data: 1151995-69-5(Hazardous Substances Data)

Usage

Description

Tubulin Polymerization Inhibitor II, derived from the combretastatin A-4 analog SU5416, is a potent anti-microtubule agent that inhibits the polymerization of tubulin, a key component in the formation of microtubules. This cell-permeable compound exhibits strong anti-proliferative activity against various cancer cell lines, making it a promising candidate for cancer treatment.

Uses

Used in Anticancer Applications:
Tubulin Polymerization Inhibitor II is used as an anticancer agent for its ability to disrupt the formation of microtubules, which are essential for cell division and maintenance of cell structure. By inhibiting tubulin polymerization, this compound can effectively halt the proliferation of cancer cells, making it a valuable tool in the fight against various types of cancer.
Used in Drug Delivery Systems:
In order to enhance the efficacy and bioavailability of Tubulin Polymerization Inhibitor II, it can be incorporated into drug delivery systems. These systems, which may include organic and metallic nanoparticles, can help improve the compound's delivery to target cancer cells, potentially increasing its therapeutic outcomes and reducing side effects.
Used in Research and Development:
Tubulin Polymerization Inhibitor II is also used as a research tool for studying the role of microtubules in cell division and cancer progression. Its potent anti-microtubule activity makes it a valuable asset in the development of new cancer therapies and in understanding the underlying mechanisms of cancer cell growth and division.

Biochem/physiol Actions

Cell permeable: yes