1152029-16-7

Usage

Uses

Used in Pharmaceutical Industry:
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol is used as a key intermediate in the synthesis of new drugs due to its unique chemical structure and properties. (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol's high chemical stability and lipophilicity facilitate its interaction with biological targets, potentially leading to the development of novel therapeutic agents.
Used in Agrochemical Industry:
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol is used as a building block in the design of new agrochemicals, such as pesticides and herbicides. Its chemical stability and lipophilicity allow for better absorption and distribution in plants, enhancing the effectiveness of these agrochemicals.
Used in Other Industrial Applications:
(1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol may also find applications in various other industries, such as materials science, where its unique properties can be utilized to develop new materials with specific characteristics. (1R,2S)-2-amino-1-[3,5-bis(trifluoromethyl)phenyl]propan-1-ol's potential uses are vast, and further research is needed to fully explore its capabilities.

Upstream product

• 877384-16-2 benzyl (1S,2R)-2-(3,5-bis(trifluoromethyl)phenyl)-2-hydroxy-1-methylethylcarbamate 
• 871917-79-2 benzyl {(1S)-2-[3,5-bis(trifluoromethyl)phenyl]-1-methyl-2-oxoethyl}carbamate 

Downstream Products

• 875444-06-7 (4S,5S)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 875444-10-3 (4R,5S)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 875444-08-9 (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 875444-05-6 (4R,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-1,3-oxazolidin-2-one 
• 1620289-77-1 (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[(E)-({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methylidene)amino]propan-1-ol 
• 1220703-07-0 (1R,2S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-[({2-[4-fluoro-2-methoxy-5-(propan-2-yl)phenyl]-5-(trifluoromethyl)phenyl}methyl)amino]propan-1-ol 
• 875446-37-0 anacetrapib 
• 1621255-72-8 (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(5-bromo-2-methoxypyridin-3-yl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol 
• 1621255-99-9 (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(3-chloro-5-fluorophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol 
• 1621255-98-8 (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(3-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)mehylamino)propan-1-ol 
• 1621255-75-1 (1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-2-((2-(4-fluoro-2-methoxy-5-nitrophenyl)-5,5-dimethylcyclohex-1-enyl)methylamino)propan-1-ol 
• 1621254-48-5 methyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-3-fluorobenzoate 
• 1621254-42-9 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-3-methylbenzoic acid 
• 1621254-41-8 methyl 4-(4-(2-(((4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyl-2-oxooxazolidin-3-yl)methyl)-4,4-dimethylcyclohex-1-enyl)-5-methoxypyrimidin-2-yl)-3-methylbenzoate 

Relevant academic research and scientific papers

PROCESS FOR PREPARATION OF ANACETRAPIB AND INTERMEDIATES THEREOF

The present invention relates to a novel process for the preparation of anacetrapib. The present invention also relates to novel intermediate or its salt and its use in the preparation of anacetrapib.

CETP INHIBITORS

Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the