1152032-92-2Relevant academic research and scientific papers
Nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds with PhSCF2H in the presence of a phosphazene as a base
Punirun, Teerachai,Soorukram, Darunee,Kuhakarn, Chutima,Reutrakul, Vichai,Pohmakotr, Manat
, p. 4162 - 4169 (2014/07/08)
Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds has been achieved by use of difluoro(phenylsulfanyl)methane (PhSCF2H) and the phosphazene base P4-tBu in THF. Non-enolizable aldehydes and ketones are suitable substrates to undergo nucleophilic gem-difluoro(phenylsulfanyl)methylation, providing α-gem-difluoromethylated adducts in good yields. In addition, this methodology is also applicable with cyclic imides and acid anhydrides. Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of aromatic aldehydes and ketones, cyclic imides, and acid anhydrides with difluoro(phenylsulfanyl)methane (PhSCF2H) reagent was achieved in the presence of the phosphazene P4-tBu as a base. The corresponding adducts should be useful for further synthetic conversion into a variety of fluorinated compounds. Copyright
Fluoride-catalyzed addition of PhSCF2SiMe3 to N-substituted cyclic imides followed by radical cyclization: General synthetic strategy of gem-difluoromethylenated 1-azabicyclic compounds
Bootwicha, Teerawut,Panichakul, Duanghathai,Kuhakarn, Chutima,Prabpai, Samran,Kongsaeree, Palangpon,Tuchinda, Patoomratana,Reutrakul, Vichai,Pohmakotr, Manat
supporting information; experimental part, p. 3798 - 3805 (2009/10/01)
(Chemical Equation Presented) PhSCF2SiMe3 (1) was found, for the first time, to undergo fluoride-catalyzed nucleophilic difluoro(phenylsulfanyl)methylation reaction to cyclic imides 2, affording the corresponding adducts 3 in moderat
