1152034-94-0

Basic information

• Product Name: 2-(2-chlorophenyl)-N-cyclohexylimidazolo[1,2-a]pyridin-3-amine
• Synonyms: 2-(2-chlorophenyl)-N-cyclohexylimidazolo[1,2-a]pyridin-3-amine
• CAS NO: 1152034-94-0
• Molecular Weight: 325.841
• Mol File: 1152034-94-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(2-chlorophenyl)-N-cyclohexylimidazolo[1,2-a]pyridin-3-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-chlorophenyl)-N-cyclohexylimidazolo[1,2-a]pyridin-3-amine(1152034-94-0)
• EPA Substance Registry System: 2-(2-chlorophenyl)-N-cyclohexylimidazolo[1,2-a]pyridin-3-amine(1152034-94-0)

Safety Data

• Hazardous Substances Data: 1152034-94-0(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 931-53-3 Cyclohexyl isocyanide 
• 17849-38-6 2-Chlorobenzyl alcohol 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 54979-78-1 2-chloro-N-(pyridine-2-yl)benzamide 
• 504-29-0 2-aminopyridine 
• 108-91-8 cyclohexylamine 
• 2387-23-7 1,3-Dicyclohexylurea 

Relevant articles and documents

Identification of a 3-aminoimidazo[1,2-a]pyridine inhibitor of HIV-1 reverse transcriptase

Background: Despite the effectiveness of highly active antiretroviral therapy (HAART), there remains an urgent need to develop new human immunodeficiency virus type 1 (HIV-1) inhibitors with better pharmacokinetic properties that are well tolerated, and t

Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the Groebke reaction and a subset of compounds prepared from 2-chlorobenzaldehyde, cyclohexyl isocyanide and a 6-substituted 2-aminopyridine showed good inhibitory activity in enzymatic (RT) and HIV anti-infectivity MAGI whole cell assays. The compound showing the best anti-HIV-1 IIIB whole cell activity (MAGI IC50 = 0.18 μM, IC90 = 1.06 μM), along with a good selectivity index (>800), was 2-(2-chlorophenyl)-3- (cyclohexylamino)imidazo[1,2-a]pyridine-5-carbonitrile 38.