1152035-02-3

Upstream product

• 504-29-0 2-aminopyridine 
• 931-53-3 Cyclohexyl isocyanide 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 504-29-0 2-aminopyridine 

Relevant academic research and scientific papers

Magnetic mesoporous poly-melamine–formaldehyde: an efficient and recyclable catalyst for straightforward one-pot synthesis of imidazo[1,2-a]pyridines

Abstract: Magnetically separable mesoporous poly-melamine–formaldehyde nanocomposite (Fe3O4@mPMF) has been synthesized and characterized by FTIR spectroscopy, SEM, XRD spectroscopy and EDS. The magnetically separable Fe3O

Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of α-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as α-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some α-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

Three novel sequential reactions for the facile synthesis of a library of bisheterocycles possessing the 3-aminoimidazo[1,2- a ]pyridine core catalyzed by bismuth(III) chloride

Novel, one-pot, two-step, sequential protocols for the synthesis of 1,4-phenylene bisheterocyclic compounds have been developed. Successive sequencing of the Groebke-Blackburn-Bienaymé reaction with Ugi-azide, Hantzsch and Biginelli reactions results in rapid and efficient formation of bisheterocyclic compounds. A simple, fast and high yielding method for the synthesis of 3-aminoimidazo[1,2-a]pyridines catalyzed by bismuth(III) chloride under solvent-free conditions is reported. Bismuth(III) chloride is also an efficient catalyst for the Ugi-azide reaction under solvent free conditions. Georg Thieme Verlag Stuttgart - New York.

Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors

During random screening of a small in-house library of compounds, certain substituted imidazo[1,2-a]pyridines were found to be weak allosteric inhibitors of HIV-1 reverse transcriptase (RT). A library of these compounds was prepared using the Groebke reaction and a subset of compounds prepared from 2-chlorobenzaldehyde, cyclohexyl isocyanide and a 6-substituted 2-aminopyridine showed good inhibitory activity in enzymatic (RT) and HIV anti-infectivity MAGI whole cell assays. The compound showing the best anti-HIV-1 IIIB whole cell activity (MAGI IC50 = 0.18 μM, IC90 = 1.06 μM), along with a good selectivity index (>800), was 2-(2-chlorophenyl)-3- (cyclohexylamino)imidazo[1,2-a]pyridine-5-carbonitrile 38.

IMIDAZOPYRIDINES AND IMIDAZOPYRIMIDINES AS HIV-I REVERSE TRANSCRIPTASE INHIBITORS

The invention provides compounds of formula A or B which are useful in the treatment of a subject infected with HIV.

NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

Disclosed herein are antiviral agents, in particular non-nucleoside reverse transcriptase inhibitors (NNRTIs) of the formula. Also disclosed are methods of making the NNRTIs, as well as compositions that include such NNRTIs and methods of their use for tr