1152052-92-0Relevant academic research and scientific papers
Titanocene-promoted intermolecular couplings of epoxides with nitriles. An easy access to β-hydroxyketones
Fernandez-Mateos,Encinas Madrazo,Herrero Teijon,Rubio Gonzalez
supporting information; experimental part, p. 3913 - 3918 (2009/10/20)
(Chemical Equation Presented) Radical couplings of epoxides and nitriles mediated by Cp2TiCl provide a diastereoselective route to the synthesis of β-hydroxyketones. The conditions of this "aldol- like" reaction are mild enough to avoid the dehydration of the β-hydroxyketone. The scope of the coupling reaction with functionalized and tetrasubstituted epoxides has been studied. The radical character of the coupling reactions is demonstrated.
