1152166-54-5Relevant academic research and scientific papers
One-pot cross double-Mannich reaction of acetaldehyde catalyzed by a binaphthyl-based amino sulfonamide
Kano, Taichi,Sakamoto, Ryu,Yamaguchi, Yukako,Itoh, Ken-Ichi,Maruoka, Keiji
supporting information, p. 1118 - 1120 (2013/02/25)
A one-pot cross double-Mannich reaction of acetaldehyde was developed, and densely functionalized 1,3-diamines were obtained as a single stereoisomer by use of axially chiral amino sulfonamide (S)-1 as catalyst. Using this catalyst, the one-pot Mannich reaction-aminoxylation was also realized.
The proline-catalyzed double Mannich reaction of acetaldehyde with N-Boc imines
Chandler, Carley,Galzerano, Patrizia,Michrowska, Anna,List, Benjamin
supporting information; experimental part, p. 1978 - 1980 (2009/07/25)
(Chemical Equation Presented) Double-cross: Proline catalyzes the double Mannich reaction of acetaldehyde with N-Boc imines in excellent yields (up to 99%; Boc = tert-butoxycarbonyl) and close to perfect diastereo- and enantioselectivities. Depending on t
