1152257-45-8Relevant academic research and scientific papers
Novel peptide mimetic inhibitors of hepatitis C serine protease derived from isomannide
Barros, Thalita G.,Pinheiro, Sergio,Williamson, John S.,Tanuri, Amilcar,Pereira, Helena S.,Brindeiro, Rodrigo M.,Neto, Jose B. A.,Antunes, Octavio A. C.,Muri, Estela M. F.
, p. 620 - 626 (2009)
Hepatitis C (HCV) infection is a cause of chronic liver disease such as cirrhosis, carcinoma, or liver failure, and the current therapy is effective in only 50% of patients. Serine proteases, which are present in HCV, are the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and biological studies of a novel class of peptide mimetic compounds as potential HCV serine protease inhibitors. Georg Thieme Verlag Stuttgart.
