1152314-49-2 Usage
Uses
Used in Pharmaceutical Industry:
(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid is used as an active pharmaceutical ingredient for the development of antibiotics. Its application is based on its ability to inhibit bacterial DNA gyrase and topoisomerase IV enzymes, which are essential for DNA replication and repair, ultimately leading to the eradication of bacterial infections.
Used in Research and Development:
In the field of scientific research, (S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid is used as a key component in the study of antimicrobial agents and their mechanisms of action. It aids researchers in understanding the interactions between antibiotics and bacterial enzymes, which can contribute to the development of more effective and targeted treatments for bacterial infections.
Used in Diagnostic Applications:
(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid may also be utilized in the development of diagnostic tools and tests to identify and monitor bacterial infections. Its antimicrobial properties can be harnessed to create assays that detect the presence of specific bacteria or assess the effectiveness of antibiotic treatments.
Used in Veterinary Medicine:
In addition to human medicine, (S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid can be employed in veterinary medicine for the treatment of bacterial infections in animals. Its broad-spectrum antimicrobial activity makes it a valuable asset in maintaining the health of livestock and pets.
Used in Agricultural Applications:
(S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid may also find applications in the agricultural sector, particularly in the development of antimicrobial agents for the treatment and prevention of bacterial infections in crops and livestock. Its ability to inhibit bacterial growth can contribute to increased crop yields and improved animal health, ultimately benefiting the overall agricultural industry.
Check Digit Verification of cas no
The CAS Registry Mumber 1152314-49-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,2,3,1 and 4 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1152314-49:
(9*1)+(8*1)+(7*5)+(6*2)+(5*3)+(4*1)+(3*4)+(2*4)+(1*9)=112
112 % 10 = 2
So 1152314-49-2 is a valid CAS Registry Number.
1152314-49-2Relevant academic research and scientific papers
Rossi, Franca,Valentina, Casazza,Garavaglia, Silvia,Sathyasaikumar, Korrapati V.,Schwarcz, Robert,Kojima, Shin-Ichi,Okuwaki, Keisuke,Ono, Shin-Ichiro,Kajii, Yasushi,Rizzi, Menico
, p. 5684 - 5689 (2010)
Fluctuations in the brain levels of the neuromodulator kynurenic acid may control cognitive processes and play a causative role in several catastrophic brain diseases. Elimination of the pyridoxal 5?-phosphate dependent enzyme kynurenine aminotransferase II reduces cerebral kynurenic acid synthesis and has procognitive effects. The present description of the crystal structure of human kynurenine aminotransferase II in complex with its potent and specific primary amine-bearing fluoroquinolone inhibitor (S)-(?)-9-(4-aminopiperazin-1-yl)-8- fluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-azaphenalene-5-carboxylic acid (BFF-122) should facilitate the structure-based development of cognition-enhancing drugs. From a medicinal chemistry perspective our results demonstrate that the issue of inhibitor specificity for highly conserved PLP-dependent enzymes could be successfully addressed.
