115237-57-5Relevant academic research and scientific papers
One-pot, four-different-component annulations: flexible and efficient conversion of n-sized cycloalkenones into n+4 alkenolides
Posner, Gary H.,Asirvatham, Edward,Webb, Kevin S.,Jew, Sang-sup
, p. 5071 - 5074 (1987)
Five-, six-, and seven-membered conjugated cycloalkenones undergo one-pot conjugate addition with tri-n-butyltinlithium followed by 1,4-addition to vinyl ketones and then aldol addition to aldehydes leading to cyclic hemiketals 2. Lead tetraacetate oxidative fragmentation produces various 4-atom enlarged, vicinally disubstituted, regiospecifically and stereospecifically unsaturated macrolides 3.
