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2,3(1H)-Isoquinolinedicarboxylic acid, octahydro-, 2-(1,1-dimethylethyl) ester, (3S,4aS,8aS)-, commonly known as (-)-Tetrahydropalmatine, is a chemical compound widely used in traditional Chinese medicine. It exhibits potential sedative and analgesic effects, making it a valuable component for various medicinal applications. As a potent antagonist for dopamine receptors, it has been extensively studied for its potential in treating neurological and psychiatric disorders, as well as for alleviating chronic pain and anxiety.

115238-59-0

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115238-59-0 Usage

Uses

Used in Pharmaceutical Industry:
(-)-Tetrahydropalmatine is used as a sedative and analgesic agent for its potential calming and pain-relieving effects. Its ability to modulate dopamine receptors makes it a promising candidate for the treatment of various neurological and psychiatric disorders.
Used in Neurological and Psychiatric Treatments:
In the field of neurology and psychiatry, (-)-Tetrahydropalmatine is employed as a potential therapeutic agent for disorders such as schizophrenia and addiction. Its antagonistic action on dopamine receptors helps in managing the symptoms and improving the quality of life for patients suffering from these conditions.
Used in Chronic Pain Management:
(-)-Tetrahydropalmatine is utilized in chronic pain management due to its analgesic properties. It has been studied for its potential to alleviate persistent pain and improve the overall well-being of individuals suffering from chronic pain conditions.
Used in Anxiety Relief:
In the context of anxiety relief, (-)-Tetrahydropalmatine serves as a potential anxiolytic agent. Its calming effects and ability to modulate neurotransmitter activity contribute to reducing anxiety levels and promoting a sense of relaxation and well-being.

Check Digit Verification of cas no

The CAS Registry Mumber 115238-59-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,2,3 and 8 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 115238-59:
(8*1)+(7*1)+(6*5)+(5*2)+(4*3)+(3*8)+(2*5)+(1*9)=110
110 % 10 = 0
So 115238-59-0 is a valid CAS Registry Number.

115238-59-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S,4aS,8aS)-2-[(2-methylpropan-2-yl)oxycarbonyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names (3S,4aS,8aS)-2-(tert-Butoxycarbonyl)decahydroisoquinoline-3-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115238-59-0 SDS

115238-59-0Upstream product

115238-59-0Relevant academic research and scientific papers

Substituted piperidines as melanocortin-4 receptor agonists

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Page column 56, (2010/02/05)

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. Also provided are methods of treating sexual dysfunction with a compound that is a selective agonist of MC-4R over any other human melanocortin receptor.

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