115241-94-6

Basic information

• Product Name: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID
• Synonyms: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID;GLYCINE, N-(8-QUINOLINYLSULFONYL)-;2-[(8-QUINOLINYLSULFONYL)AMINO]ACETIC ACID
• CAS NO: 115241-94-6
• Molecular Formula: C₁₁H₁₀N₂O₄S
• Molecular Weight: 266.27
• Mol File: 115241-94-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 129 °C
• Boiling Point: 537.3 °C at 760 mmHg
• Flash Point: 278.7 °C
• Appearance: /
• Density: 1.491 g/cm³
• PKA: 3.22±0.10(Predicted)
• CAS DataBase Reference: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID(115241-94-6)
• EPA Substance Registry System: (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID(115241-94-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 115241-94-6(Hazardous Substances Data)

Usage

General Description

(QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is a chemical compound that contains a quinoline ring with a sulfonamide group attached at the 8-position and an acetic acid group. It is used in the synthesis of pharmaceuticals and research chemicals, and has been studied for its potential biological activities. The sulfonamide group in the molecule is known to confer antibacterial and diuretic properties, while the quinoline ring has shown potential as an antimalarial and antitumor agent. The acetic acid group may contribute to the compound's solubility and pharmacokinetic properties. Overall, (QUINOLINE-8-SULFONYLAMINO)-ACETIC ACID is a versatile chemical with potential applications in drug discovery and development.

Upstream product

• 18704-37-5 quinoline-8-sulfonyl chloride 

Relevant articles and documents

Identification of bidentate salicylic acid inhibitors of PTP1B

PTP1B is a master regulator in the insulin and leptin metabolic pathways. Hyper-activated PTP1B results in insulin resistance and is viewed as a key factor in the onset of type II diabetes and obesity. Moreover, inhibition of PTP1B expression in cancer cells dramatically inhibits cell growth in vitro and in vivo. Herein, we report the computationally guided optimization of a salicylic acid-based PTP1B inhibitor 6, identifying new and more potent bidentate PTP1B inhibitors, such as 20h, which exhibited a > 4-fold improvement in activity. In CHO-IR cells, 20f, 20h, and 20j suppressed PTP1B activity and restored insulin receptor phosphorylation levels. Notably, 20f, which displayed a 5-fold selectivity for PTP1B over the closely related PTPσ protein, showed no inhibition of PTP-LAR, PRL2 A/S, MKPX, or papain. Finally, 20i and 20j displayed nanomolar inhibition of PTPσ, representing interesting lead compounds for further investigation.