1152475-40-5

Basic information

• Product Name: 2-Chloro-7-iodothieno[3,2-d]pyrimidine
• Synonyms: 2-Chloro-7-iodothieno[3,2-d]pyrimidine
• CAS NO: 1152475-40-5
• Molecular Formula: C₆H₂ClIN₂S
• Molecular Weight: 296.51595
• Product Categories: Heterocycle-Pyrimidine series
• Mol File: 1152475-40-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 2-Chloro-7-iodothieno[3,2-d]pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-7-iodothieno[3,2-d]pyrimidine(1152475-40-5)
• EPA Substance Registry System: 2-Chloro-7-iodothieno[3,2-d]pyrimidine(1152475-40-5)

Safety Data

• Hazardous Substances Data: 1152475-40-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-7-iodothieno[3,2-d]pyrimidine is a specialized chemical compound belonging to the family of thienopyrimidines. 2-Chloro-7-iodothieno[3,2-d]pyrimidine has an aromatic structure composed of a thieno ring fused with a pyrimidine ring, bearing a chlorine atom at the 2nd position and an iodine atom at the 7th position. It is primarily used for research purposes and serves a crucial role as an intermediate product in the synthesis of various other chemical compounds, particularly pharmaceuticals. Despite its wide applications, it should be handled with care due to its reactivity and potential hazard if improperly used.

Upstream product

• 16234-14-3 2,4-dichlorothieno[3,2-d]pyrimidine 
• 1119280-68-0 2-chlorothieno[3,2-d]pyrimidine 

Downstream Products

• 1152473-40-9 7-iodo-N-(4-morpholinophenyl)thieno[3,2-d]pyrimidin-2-amine 
• 1152473-78-3 7-iodo-N-(3-nitrophenyl)thieno[3,2-d]pyrimidin-2-amine 

Relevant articles and documents

Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors

A series of 2,7-disubstituted-thieno[3,2-d]pyrimidine derivatives were designed, synthesized and evaluated as novel focal adhesion kinase (FAK) inhibitors. The novel 2,7-disubstituted-thieno[3,2-d]pyrimidine scaffold has been designed as a new kinase inhibitor platform that mimics the bioactive conformation of the well-known diaminopyrimidine motif. Most of the compounds potently suppressed the enzymatic activities of FAK and potently inhibited the proliferation of U-87MG, A-549 and MDA-MB-231 cancer cell lines. Among these derivatives, the optimized compound 26f potently inhibited the enzyme (IC50 = 28.2 nM) and displayed stronger potency than TAE-226 in U-87MG, A-549 and MDA-MB-231 cells, with IC50 values of 0.16, 0.27, and 0.19 μM, respectively. Compound 26f also exhibited relatively less cytotoxicity (IC50 = 3.32 μM) toward a normal human cell line, HK2. According to the flow cytometry results, compound 26f induced the apoptosis of MDA-MB-231 cells in a dose-dependent manner and effectively arrested MDA-MB-231 cells in G0/G1 phase. Further investigations revealed that compound 26f potently suppressed the migration of MDA-MB-231 cells. Collectively, these data support the further development of compound 26f as a lead compound for FAK-targeted anticancer drug discovery.