1152478-65-3Relevant academic research and scientific papers
First-in-class, dual-action, 3,5-disubstituted indole derivatives having human nitric oxide synthase (nNOS) and norepinephrine reuptake inhibitory (NERI) activity for the treatment of neuropathic pain
Mladenova, Gabriela,Annedi, Subhash C.,Ramnauth, Jailall,Maddaford, Shawn P.,Rakhit, Suman,Andrews, John S.,Zhang, Dongqin,Porreca, Frank
, p. 3488 - 3501 (2012)
A family of different 3,5-disubstituted indole derivatives having 6-membered rings were designed, synthesized, and demonstrated inhibition of human nitric oxide synthase (NOS) with norepinephrine reuptake inhibitory activity (NERI). The structure-activity
INDOLE COMPOUNDS AND METHODS FOR TREATING VISCERAL PAIN
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Page/Page column 80, (2009/06/27)
The invention features methods of treating visceral pain or a condition in a mammal caused by the action of nitric oxide synthase (NOS) or by the action of serotonin 5HT1D/1B receptors, by administering to a patient in need thereof a therapeutically effec
3,5 - SUBSTITUTED INDOLE COMPOUNDS HAVING NOS AND NOREPINEPHRINE REUPTAKE INHIBITORY ACTIVITY
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Page/Page column 31, (2009/05/28)
The present invention relates to novel 3,5-substituted indole compounds of Formula (I) having nitric oxide synthase (NOS) inhibitory activity together with inhibitory activity at the norepinephrine transporter (NET), to pharmaceutical and diagnostic compositions containing them, and to their medical use.
