115249-86-0

Relevant academic research and scientific papers

Antiviral compounds

2',3'-Dideoxy-3'-fluoro pyrimidine nucleosides particularly 2',3'-dideoxy-3'-fluorothymidine have been found to have particularly potent activity against adenovirus infections especially those caused by adenoviruses of serotype 8. Such compounds are preferably presented in pharmaceutical formulations adapted for ophthalmic administration.

Fluorinated nucleosides and method for treating retrovirus infections therewith

A method for treating AIDS, which comprises administering to a patient in need therefor a pharmaceutical composition comprising a therapeutically effective amount of a compound having the formula STR1 wherein R 1 is an adenine, cytosine, guanine, thymidine, uracil, 5-substituted uracil, 5-substituted cytosine derivative, 2-fluoroadenine, 2.6-diaminopurine, 2-aminopurine, 6-thioguanine, or 7-deazaadenine group;R 2 is H, or a OH group;R 3 is a OH, O-acyl, O-palmitoyl group, or phosphates (as free acid, or its alkali, ammonium or alkyl ammonium salts), or any other precursor group for the hydroxyl group;or a physiologically acceptable salt thereof. Furthermore, the present invention comprises the new compounds:2'',3''-dideoxy-3''-fluoro-2-fluoroadenosine,2'',3''-dideoxy-3''-fluoro-6-thioguanosine,2'',3''-dideoxy-3''-fluoro-2,6-diaminopurineriboside,2'',3''-dideoxy-3''-fluoro-2-aminopurineriboside,2'',3''-dideoxy-3''-fluoro-5-aminomethyluridine,2'',3''-dideoxy-3''-fluoro-5-azidomethyluridine, and2'',3''-dideoxy-3''-fluoro-5-hydroxymethyluridine.