1152509-06-2Relevant academic research and scientific papers
Rational design and synthesis of highly potent pharmacological chaperones for treatment of N370S mutant Gaucher disease
Wang, Guan-Nan,Reinkensmeier, Gabriele,Zhang, Si-Wei,Zhou, Jian,Zhang, Liang-Ren,Zhang, Li-He,Butters, Terry D.,Ye, Xin-Shan
supporting information; experimental part, p. 3146 - 3149 (2010/03/03)
Highly potent N-substituted δ-lactams have been rationally designed and synthesized by a concise route with a one-pot tandem reaction as key step. These iminosugars show weak inhibition of wildtype β-glucocerebrosidase but 3- to 6-fold increases in mutant
