1152550-37-2

Upstream product

• 1135351-95-9 4-bromo-N-(tert-butyl)-2-nitroaniline 
• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 

Downstream Products

• 1310532-10-5 2-(5-bromo-1-tert-butyl-1H-benzimidazol-2-yl)benzonitrile 
• 1310531-68-0 N₁-tert-butyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1l,2-diamine 
• 1374150-60-3 C₁₈H₁₆BrN₃ 
• 1374150-48-7 C₁₉H₁₉BrN₂O₂ 
• 1374150-61-4 C₂₂H₂₀N₆ 
• 1374150-10-3 3-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-benzamide 
• 1374150-62-5 C₁₈H₁₆BrN₂O₂^(1-)*Li⁽¹⁺⁾ 
• 1374150-13-6 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-benzamide 
• 1374150-49-8 C₁₉H₂₀BrN₃O 
• 1374149-76-4 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-N-methyl-benzamide 
• 1579951-65-7 (4bR,7S,9aS,10aS)-7-((5-bromo-1-(tert-butyl)-1H-benzo[d][1,2,3]triazol-4-yl)methyl)-9a-methyl-7-(2-phenoxyethyl)-7,8,9,9a,10a,11-hexahydroindeno[1′,2′:4,5]-oxazolo[3,2-a]pyridin-6(4bH)-one 
• 1579951-67-9 C₂₅H₂₉N₃O₃ 
• 1398510-92-3 (S)-3-(tert-butyl)-9a-(2-phenoxyethyl)-8,9,9a,10-tetrahydrofluoreno[1,2-d][1,2,3]triazol-7(3H)-one 
• 1310531-76-0 5-bromo-1-tert-butyl-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]-1H-benzimidazole 

Relevant academic research and scientific papers

Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition

Herein we describe a series of tetrahydrobenzotriazoles as novel, potent metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulators (PAMs). Exploration of the SAR surrounding the tetrahydrobenzotriazole core ultimately led to the ide

Enantioselective synthesis of a highly substituted tetrahydrofluorene derivative as a potent and selective estrogen receptor beta agonist

The development and execution of a practical asymmetric synthesis of the estrogen receptor beta selective agonist (8R,10aS)-6-(trifluoromethyl)-8,9,10, 11-tetrahydro-8,10a-methanocyclohepta[1,2]indeno[4,5-d][1,2,3]triazol-7(3H)-one is described. The optimized route features a key chiral auxiliary-mediated dialkylation approach to set the all-carbon quaternary center with exceptional stereocontrol. Overall, the chemistry has been used to prepare >30 kg of drug candidate in 21% overall yield through 13 longest linear steps and with >99% ee.

BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula IA and IB and pharmaceutically acceptable salts thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds,

BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I) and pharmaceutically acceptable salt thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, method