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(1-Methyl-1H-pyrazol-4-yl)-acetic acid, also known as MAPA, is a synthetic compound characterized by a pyrazole ring with a methyl group at the 1-position and an acetic acid moiety at the 4-position. It is not found naturally and is primarily utilized in research and pharmaceutical fields. MAPA has garnered interest due to its potential anti-inflammatory and neuroprotective properties, as well as its capacity to inhibit specific enzymes, which may contribute to its use in the development of novel therapeutics for a range of medical conditions. Further research is essential to fully explore and understand the compound's potential applications.

1152582-56-3

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1152582-56-3 Usage

Uses

Used in Pharmaceutical Research:
(1-Methyl-1H-pyrazol-4-yl)-acetic acid is used as a research compound for its potential anti-inflammatory and neuroprotective properties, which are being studied for the development of new drugs to treat various medical conditions.
Used in Enzyme Inhibition Studies:
In the field of biochemistry, (1-Methyl-1H-pyrazol-4-yl)-acetic acid is used as an inhibitor of certain enzymes, which can be crucial for understanding enzyme functions and developing targeted therapies.
Used in Drug Development:
(1-Methyl-1H-pyrazol-4-yl)-acetic acid is utilized in the development of new drugs, given its potential to modulate biological processes and target specific pathways implicated in various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 1152582-56-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,2,5,8 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1152582-56:
(9*1)+(8*1)+(7*5)+(6*2)+(5*5)+(4*8)+(3*2)+(2*5)+(1*6)=143
143 % 10 = 3
So 1152582-56-3 is a valid CAS Registry Number.

1152582-56-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(1-methylpyrazol-4-yl)acetic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1152582-56-3 SDS

1152582-56-3Downstream Products

1152582-56-3Relevant academic research and scientific papers

Synthesis of 1-hetaryl-2,2-difluorocyclopropane-derived building blocks: The case of pyrazoles

Nosik, Pavel S.,Ryabukhin, Sergey V.,Pashko, Mykola O.,Grabchuk, Galyna P.,Grygorenko, Oleksandr O.,Volochnyuk, Dmitriy M.

, p. 80 - 89 (2019)

An approach to 1-hetaryl-2,2-difluorocyclopropane building blocks compatible with the current criteria of lead-oriented synthesis was developed and implemented for the case of 3-, 4- and 5-subsituted pyrazole derivatives. The method implied 6–9 synthetic steps, including difluorocyclopropanation with the TMSCF3–NaI system as the key transformation, and provided the title compounds on up to gram scale. The scope of the procedures towards substitution in the pyrazole ring and typical functional groups (i.e. COOH, NH2, CH2NH2, CH2OH) was established. The results obtained allowed formulation of preliminary guidelines for the synthetic feasibility of various functionalized 1-hetaryl-2,2-difluorocyclopropanes. 2018 Elsevier Ltd. All rights reserved.

Small-molecule inhibitors of the interaction between the E3 ligase VHL and HIF1α

Buckley, Dennis L.,Gustafson, Jeffrey L.,Van-Molle, Inge,Roth, Anke G.,Tae, Hyun Seop,Gareiss, Peter C.,Jorgensen, William L.,Ciulli, Alessio,Crews, Craig M.

supporting information, p. 11463 - 11467 (2013/01/15)

By design: Novel small-molecule inhibitors of the interaction between the von Hippel-Lindau ligase (VHL) and its molecular target HIF1α, a transcription factor involved in oxygen sensing, have been developed and studied. The most potent inhibitor binds with an IC50 value of 0.9-μM and is thus the first sub-micromolar inhibitor of the VHL-HIF1α interaction. Copyright

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