1152589-31-5Relevant academic research and scientific papers
Synthesis of Enantioenriched Allylic Silanes via Nickel-Catalyzed Reductive Cross-Coupling
Hofstra, Julie L.,Cherney, Alan H.,Ordner, Ciara M.,Reisman, Sarah E.
supporting information, p. 139 - 142 (2018/01/17)
An asymmetric Ni-catalyzed reductive cross-coupling has been developed to prepare enantioenriched allylic silanes. This enantioselective reductive alkenylation proceeds under mild conditions and exhibits good functional group tolerance. The chiral allylic silanes prepared here undergo a variety of stereospecific transformations, including intramolecular Hosomi-Sakurai reactions, to set vicinal stereogenic centers with excellent transfer of chirality.
Syntheses of all stereoisomers of goniodiol from yeast-reduction products and their antimicrobiological activity
Yoshida, Takahiro,Yamauchi, Satoshi,Tago, Ryosuke,Maruyama, Masafumi,Akiyama, Koichi,Sugahara, Takuya,Kishida, Taro,Koba, Yojiro
, p. 2342 - 2352 (2008/12/23)
All stereoisomers of goniodiol were synthesized from yeast-reduction products. The C-6 chiral centers were converted from the chiral centers of the yeast-reduction products. Stereoselective conversion of the alkene, which had been prepared from the yeast-reduction product, to glycol constructed the C-7 and C-8 stereochemistry. (+)-Goniodiol and 7-epi-(+)-goniodiol showed the highest antibacterial activity (MIC, 3.1 mM) against Yersinia intermedia.
