1152589-89-3Relevant academic research and scientific papers
Syntheses of all stereoisomers of goniodiol from yeast-reduction products and their antimicrobiological activity
Yoshida, Takahiro,Yamauchi, Satoshi,Tago, Ryosuke,Maruyama, Masafumi,Akiyama, Koichi,Sugahara, Takuya,Kishida, Taro,Koba, Yojiro
, p. 2342 - 2352 (2008/12/23)
All stereoisomers of goniodiol were synthesized from yeast-reduction products. The C-6 chiral centers were converted from the chiral centers of the yeast-reduction products. Stereoselective conversion of the alkene, which had been prepared from the yeast-reduction product, to glycol constructed the C-7 and C-8 stereochemistry. (+)-Goniodiol and 7-epi-(+)-goniodiol showed the highest antibacterial activity (MIC, 3.1 mM) against Yersinia intermedia.
