115263-74-6

Upstream product

• 85217-69-2 cinnamyl methyl carbonate 
• 1076-26-2 1-methyl-2-naphthol 
• 673-32-5 1-Phenylprop-1-yne 
• 300-57-2 allylbenzene 
• 4393-06-0 1-Phenyl-2-propen-1-ol 

Relevant academic research and scientific papers

Ni-Catalyzed Allylic Dearomatization Reaction of β-Naphthols with Allylic Alcohols

Ni-catalyzed intermolecular allylic dearomatization reaction of β-naphthols with allylic alcohols was achieved. By utilizing Ni(cod)2 as a catalyst precursor, DPEphos as a ligand and 4 ? molecular sieves as additives, the dearomatization reaction of β-naphthols with aryl allylic alcohols proceeded smoothly under mild conditions, affording the desired β-naphthalenone products bearing a quaternary carbon center in moderate to good yields with excellent linear selectivity.

Redox-Neutral Atom-Economic Pd(0)-Catalyzed Dearomatization of β-Naphthols with Alkynes toward Naphthalenones

A dearomative coupling of β-naphthols with alkynes via Pd hydride catalysis has been developed. This redox-neutral strategy provides a straightforward platform to access diverse naphthalenones bearing congested quarternary stereocenters with excellent atom and step economy since no leaving groups are needed to preinstall on the allylic reagents. The overall utility of this protocol is exemplified by broad functional group compatibility and gram-scale capacity.

Direct Allylic C(sp3)-H Alkylation with 2-Naphthols via Cooperative Palladium and Copper Catalysis: Construction of Cyclohexadienones with Quaternary Carbon Centers

Oxidative allylic C-H alkylation with 2-naphthols was accomplished with excellent chemoselectivities and broad substrate scope through Pd(PPh3)4/Cu(MeCN)4PF6 cooperative catalysis under mild base-free conditions. Special tolerance was observed with peptides, allowing late-stage modifications of peptides. The transformation provides a general protocol to obtain functionalized cyclohexadienones with quaternary carbon centers under two alternative sets of conditions and serves as a complementary catalysis system for the dearomatization of 2-naphthols.

Palladium-catalyzed intermolecular allylic dearomatization reaction of α-substituted β-naphthol derivatives: Scope and mechanistic investigation

A highly efficient dearomatization reaction of α-substituted β-naphthols with excellent chemoselectivity and regioselectivity has been developed. Mechanistic studies demonstrated that the dearomatized alkylation product is the thermodynamically more stable compound. The etherification product could be further transformed to the dearomatization product.