115264-98-7

Basic information

• Product Name: C₂₅H₂₄N₂O₁₁P^(1-)*Li⁽¹⁺⁾
• Synonyms: C₂₅H₂₄N₂O₁₁P^(1-)*Li⁽¹⁺⁾
• CAS NO: 115264-98-7
• Molecular Weight: 566.387
• Mol File: 115264-98-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₄N₂O₁₁P^(1-)*Li⁽¹⁺⁾(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₄N₂O₁₁P^(1-)*Li⁽¹⁺⁾(115264-98-7)
• EPA Substance Registry System: C₂₅H₂₄N₂O₁₁P^(1-)*Li⁽¹⁺⁾(115264-98-7)

Safety Data

• Hazardous Substances Data: 115264-98-7(Hazardous Substances Data)

Upstream product

• 613-90-1 benzoyl cyanide 
• 115265-67-3 C₁₁H₁₆N₂O₉P^(1-)*Li⁽¹⁺⁾ 

Downstream Products

• 115288-15-8 C₄₈H₄₃N₄O₁₈P 
• 115264-86-3 C₄₆H₆₁N₄O₁₇PSi₂ 
• 115264-87-4 C₅₄H₆₆N₇O₁₆PSi₂ 

Relevant articles and documents

SYNTHESIS OF PHOSPHONYLMETHYL ANALOGUES OF DIRIBONUCLEOSIDE MONOPHOSPHATES CONTAINING MODIFIED INTERNUCLEOTIDE BOND

Two types of (2'-5')- and (3'-5')-isomers of analogues of diribonucleoside monophosphates derived from O-phosphonylmethyl derivatives of ribonucleosides, differing in the position of the methylene group in the internucleotide bond (type A,B,C, and D) have been synthesized.The compounds were prepared from methyl esters of O-phosphonylmethylribonucleosides I and XVII by a procedure analogous to the phosphotriester method of oligonucleotide synthesis.The phosphonate moiety was protected with the methyl group.After protection of the hydroxyl or amino groups, the compounds I or XVII were condensed with protected ribonucleosides VIII, XI, XIV, XXIII to afford the neutral diesters IX, XII, XV, XXIV, XXVI, and XXVIII which were isolated by short column chromatography on silica gel.Deprotection, ion-exchange chromatography, and semipreparative HPLC gave (2'-5')- and (3'-5')-isomers of both types of O-phosphonylmethyl analogues of diribonucleoside monophosphates (X, XIII and XXV, XXVII).All these compounds are resistant towards cleavage with ribonucleases A and T2 and with snake venom exonuclease.Under conditions of alkaline hydrolysis of RNA, the analogues of the type A and B are completely stable whereas compounds of the type C and D are degraded to form 2'- or 3'-O-phosphonylmethylribonucleosides and 3'-terminal ribonucleosides.