1152841-53-6

Upstream product

• 39753-81-6 ethyl 2-(4-nitro-1H-pyrazol-1-yl)acetate 

Downstream Products

• 1450900-24-9 C₁₇H₂₀N₄O₅ 
• 1450900-23-8 C₂₀H₂₆N₄O₅S 
• 1450900-22-7 C₃₁H₃₂N₄O₆ 
• 1450900-21-6 C₂₀H₂₆N₄O₅ 
• 1450900-19-2 C₂₄H₂₆N₄O₅ 
• 1420891-21-9 C₁₇H₁₇ClFN₇O₂ 
• 1420892-71-2 (S)-ethyl 2-(4-((5-chloro-4-((1-(2-fluorophenyl)-2-hydroxyethyl)amino)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)acetate 

Relevant academic research and scientific papers

Five-And-Six-Membered Heterocyclic Compound, And Preparation Method, Pharmaceutical Composition And Use Thereof

A five-and-six-membered heterocyclic compound as represented by general formula I, pharmaceutically acceptable salt, metabolite, metabolic precursors or drug precursors thereof, preparation method, pharmaceutical composition, and use thereof; the five-and-six-membered heterocyclic compound has activity as a Janus kinase (JAK) inhibitor, and can be used to prepare drugs for treating diseases caused by the abnormal activity of kinase, such as cell proliferation diseases like cancer.

HETEROCYCLYL PYRIMIDINE ANALOGUES AS TYK2 INHIBITORS

The present invention relates to compounds of formula (I), wherein R, R1, X1 to X5 have the meaning as cited in the description and the claims. Said compounds are useful as TYK2 inhibitors for the treatment or prophylaxis