Cas 1152889-01-4,[2-(3-bromobenzylamino)phenyl]methanol

1152889-01-4

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Basic information

Product Name: [2-(3-bromobenzylamino)phenyl]methanol
Synonyms: [2-(3-bromobenzylamino)phenyl]methanol
CAS NO:1152889-01-4
Molecular Formula:
Molecular Weight: 292.175
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: [2-(3-bromobenzylamino)phenyl]methanol(CAS DataBase Reference)
NIST Chemistry Reference: [2-(3-bromobenzylamino)phenyl]methanol(1152889-01-4)
EPA Substance Registry System: [2-(3-bromobenzylamino)phenyl]methanol(1152889-01-4)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1152889-01-4(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1152889-01-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,2,8,8 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1152889-01:
(9*1)+(8*1)+(7*5)+(6*2)+(5*8)+(4*8)+(3*9)+(2*0)+(1*1)=164
164 % 10 = 4
So 1152889-01-4 is a valid CAS Registry Number.

1152889-01-4Upstream product

1160244-21-2 2-(3-bromophenyl)-1,4-dihydro-2H-benzo[d][1,3]oxazine

1152889-01-4Downstream Products

1152889-01-4Relevant academic research and scientific papers

Analogues of morphanthridine and the tear gas dibenz[ b, f ][1,4]oxazepine (CR) as extremely potent activators of the human transient receptor potential ankyrin 1 (TRPA1) channel

Gijsen, Harrie J. M.,Berthelot, Didier,Zaja, Mirko,Br?ne, Bert,Geuens, Ivo,Mercken, Marc

experimental part, p. 7011 - 7020 (2010/11/18)

The TRPA1 channel can be considered as a key biological sensor to irritant chemicals. In this paper, the discovery of 11H-dibenz[b,e]azepines (morphanthridines) and dibenz[b,f][1,4]oxazepines is described as extremely potent agonists of the TRPA1 receptor. This has led to the discovery that most of the known tear gases are potent TRPA1 activators. The synthesis and biological activity of a number of substituted morphanthridines and dibenz[b,f][1,4]oxazepines have given insight into the SAR around this class of TRPA1 agonists, with EC50 values ranging from 1 μM to 0.1 nM. Compounds 6 and 32 can be considered as the most potent TRPA1 agonists known to date, with 6 now being used successfully as a screening tool in the discovery of TRPA1 antagonists. The use of ligands such as 6 and 32 as pharmacological tools may contribute to the basic knowledge of the TRPA1 channel and advance the development of TRPA1 antagonists as potential treatment for conditions involving TRPA1 activation, including asthma and pain.

DIBENZOAZEPINE AND DIBENZOOXAZEPINE TRPA1 AGONISTS

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Page/Page column 13, (2009/07/17)

The present invention is related to novel tricyclic compounds of formula (I) having TRPA1 receptor agonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use as pharmacologi

3,4-DIHYDROPYRIMIDINE TRPA1 ANTAGONISTS

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Page/Page column 35-36, (2009/12/28)

The present invention is related to novel 3,4-dihydropyrimidine compounds of formula (I) having TRPA1 receptor antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use

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