1152931-40-2Relevant academic research and scientific papers
1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis
Abay, Efrem,Barry, Clifton E.,Basarab, Gregory S.,Boshoff, Helena I. M.,Boyle, Grant A.,Chibale, Kelly,Eyermann, Charles J.,Fienberg, Stephen,Ghorpade, Sandeep R.,Khonde, Lutete Peguy,Lawrence, Nina,Lenaerts, Anne J.,Massoudi, Lisa M.,Myers, Timothy G.,Myrick, Alissa,Nchinda, Aloysius T.,Njoroge, Mathew,Reddy, Virsinha,Robertson, Gregory T.,Singh, Vinayak,Sirgel, Frederick A.,Su, Qin,Van Helden, Paul D.,Müller, Rudolf
supporting information, p. 12790 - 12807 (2021/09/11)
Phenotypic whole cell high-throughput screening of a μ150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-activity
Synthesis of 3-(1, 3-diphenyl-1H-pyrazol-4-yl) propanoic acids using diimide reduction
Deepa,Babu, V. Harinadha,Parameshwar,Reddy, B. Madhava
, p. 420 - 424 (2012/06/01)
Pyrazole-1H-4-yl-acrylic acids (3a-j) were prepared from pyrazole-1H-4-carbaldehydes which in turn were prepared by the Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j). The reaction of pyrazole-1H- 4-yl-acrylic acids to 3-(1, 3-diphenyl-1H
Synthesis of some 2-({(2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl) prop-2-enoyl} amino) benzoic acids as antiinflammatory agents
Hari Priya,Madhava Reddy,Harinadha Babu
, p. 305 - 308 (2013/09/24)
Vilsmeier-Haack reaction of substituted phenyl hydrazone derivatives (1a-j) afforded 1,3-substituted diphenyl-1H-pyrazole-4-carbaldehydes (2a-j). Compounds (2a-j) on condensation with malonic acid gave (2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl) acrylic acids (3a-j) which on reaction with thionyl chloride afforded acryloyl chlorides. The reaction of acryloyl chlorides with anthranilic acid gave 2-({(2E)-3-(1,3-substituted diphenyl-1H-pyrazol-4-yl) prop-2-enoyl} amino) benzoic acids (4a-j) in good yields. The structures of the newly synthesized compounds have been confirmed on the basis of physical and spectral data. Some of the synthesized compounds have shown significant antiiflammatory actiivty.
Synthesis and biological evaluation of some novel 3-(1,3-diphenyl-1H- pyrazol-4-yl) propanoic acids
Deepa,Harinadha Babu,Madhava Reddy
, p. 213 - 216 (2013/09/24)
Vilsmeier-Haack reaction of phenyl hydrazone derivatives (1a-j) afforded 1,3-diphenyl-1 W-pyrazole-4-carbaldehydes (2a-j). Condensation of (2a-j) with malonic acid gave 3-(1,3-diphenyl-1/-/-pyrazol-4-yl) acrylic acids (3a-j. Reduction of (3a-j) gave 3-(1,
