1153025-67-2

Upstream product

• 100-01-6 4-nitro-aniline 
• 3433-80-5 1-Bromo-2-bromomethyl-benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 386758-32-3 C₁₃H₉BrN₂O₂ 

Downstream Products

• 1393689-07-0 tert-butyl 2-(2-(4-nitrophenyl)isoindolin-1-yl)acetate 
• 1394134-54-3 N-(2-bromobenzyl)-N-methyl-4-nitroaniline 

Relevant academic research and scientific papers

Intramolecular direct dehydrohalide coupling promoted by KOtBu: Total synthesis of amaryllidaceae alkaloids anhydrolycorinone and oxoassoanine

A transition-metal-free intramolecular dehydrohalide coupling via intramolecular homolytic aromatic substitution (HAS) with aryl radicals has been developed in the presence of potassium tert-butoxide and an organic molecule as the catalyst. The methodology has been applied to a concise synthesis of Amaryllidaceae alkaloids viz. oxoassoanine (1b), anhydrolycorinone (1d), and other related structures. Interestingly, the method also works only in the presence of potassium tert-butoxide.

A tandem Heck-aza-Michael addition protocol for the one-pot synthesis of isoindolines from unprotected amines

A palladacycle-catalyzed tandem Heck-intramolecular aza-Michael reaction protocol has been developed for the one-pot synthesis of 1-substituted isoindolines from N-unprotected 2-bromobenzylamines and acrylates with high yields.