115310-98-0

Basic information

• Product Name: 2,4-Dimethyl-8-hydroxyquinoline
• Synonyms: 8-QUINOLINOL, 2,4-DIMETHYL- (9CI);2,4-DIMETHYL-QUINOLIN-8-OL;2,4-Dimethyl-8-hydroxyquinoline;2,4-Dimethyl-8-quinolinol;8-QUINOLINOL, 2,4-DIMETHYL-
• CAS NO: 115310-98-0
• Molecular Formula: C₁₁H₁₁NO
• Molecular Weight: 173.21
• Product Categories: API intermediates
• Mol File: 115310-98-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 64-66 °C
• Boiling Point: 303.86°C (rough estimate)
• Flash Point: 150.6 °C
• Appearance: /
• Density: 1.0898 (rough estimate)
• Vapor Pressure: 0.000122mmHg at 25°C
• Refractive Index: 1.4950 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: pK1:6.20(+1);pK2:10.60(0) (25°C)
• CAS DataBase Reference: 2,4-Dimethyl-8-hydroxyquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethyl-8-hydroxyquinoline(115310-98-0)
• EPA Substance Registry System: 2,4-Dimethyl-8-hydroxyquinoline(115310-98-0)

Safety Data

• Hazardous Substances Data: 115310-98-0(Hazardous Substances Data)

Usage

General Description

2,4-Dimethyl-8-hydroxyquinoline, also known as 8-hydroxy-2,4-dimethylquinoline, is an organic compound with the chemical formula C11H11NO. It is a derivative of quinoline and is commonly used as an antioxidant and chelating agent in various industrial and pharmaceutical applications. 2,4-Dimethyl-8-hydroxyquinoline has been shown to exhibit antimicrobial, anticancer, and anti-inflammatory properties, making it a valuable chemical in the field of medicine and drug development. Additionally, it is used in the production of rubber and as a metal chelating agent in the production of lubricants and grease. 2,4-Dimethyl-8-hydroxyquinoline is considered to be relatively non-toxic and is generally regarded as safe for use in these applications.

InChI:InChI=1/C11H11NO/c1-7-6-8(2)12-11-9(7)4-3-5-10(11)13/h3-6,13H,1-2H3

Upstream product

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• 899797-71-8 4-(3-hydroxyphenyl)pentan-2-one 
• 191614-96-7 4-(3-hydroxyphenyl)pentan-2-one O-(2,4-dinitrophenyl)oxime 
• 123-63-7 paracetaldehyde 

Downstream Products

• 635697-81-3 2-[2,4-dichloro-3-(2,4-dimethylquinolin-8-yloxymethyl)benzenesulfonylamino]-2-methylpropionic acid tert-butyl ester 
• 844435-94-5 C₃₈H₃₁AlN₂O₃ 
• 635697-97-1 lithium (R)-2-[2,4-dichloro-3-(2,4-dimethyl-8-quinolinyloxymethyl)-benzenesulfonamido]-2-methylbutanoate 
• 883969-07-1 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-tetrahydropyran-4-carboxylic acid methyl ester 
• 298706-32-8 bis(2,4-dimethyl-8-quinolinolato)(triphenylsilanolato)aluminum (III) 
• 167834-56-2 8-(2,6-Dichloro-3-nitro-benzyloxy)-2-methyl-quinoline 
• 202603-17-6 1-[(3-Bromomethyl-4-chloro-2-methoxyphenyl)sulfonyl]-L-proline methyl ester 
• 635697-88-0 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester 
• 928851-48-3 4-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 

Relevant articles and documents

Synthesis of 8-hydroxyquinolines by the cyclization of m-hydroxyphenethyl ketone O-2,4-dinitrophenyloximes

8-Hydroxyquinolines are synthesized from O-2,4-dinitrophenyloximes of m-hydroxyphenethyl ketones by the treatment with sodium hydride, and then with 2,3-dichloro4,5-dicyano-p-benzoquinone (DDQ).

ALUMINUM CHELATE COMPLEX FOR ORGANIC EL MATERIAL

This invention provides an organic EL material useful for the emissive layer of an organic EL element which deteriorates little in luminance when operated over a prolonged period of time and shows excellent durability. The material is an aluminum chelate

Regioselective synthesis of quinolin-8-ols and 1,2,3,4- tetrahydroquinolin-8-ols by the cyclization of 2-(3-hydroxyphenyl)ethyl ketone 0-2,4-dinitrophenyloximes

Cyclization of 2-(3-hydroxyphenyl)ethyl ketone 0-2,4- dinitrophenyloximes proceeds on the oxime nitrogen atom by the treatment with NaH and then with 2,3-dichloro-5,6-dicyano-p-benzoquinone and acetic acid to yield quinolin-8-ols regioselectively. The reaction in the presence of Na[BH3(CN)] affords 1,2,3,4-tetrahydroquinolin-8-ols. The present cyclization proceeds via alkylideneaminyl radical intermediates generated by the single electron transfer between 3-hydroxyphenyl and 2,4-dinitrophenyl moieties.