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115315-94-1

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115315-94-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 115315-94-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,3,1 and 5 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 115315-94:
(8*1)+(7*1)+(6*5)+(5*3)+(4*1)+(3*5)+(2*9)+(1*4)=101
101 % 10 = 1
So 115315-94-1 is a valid CAS Registry Number.

115315-94-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 2-phenylpyrazole-3-carboxylate

1.2 Other means of identification

Product number -
Other names 1H-Pyrazole-5-carboxylic acid,1-phenyl-,ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115315-94-1 SDS

115315-94-1Relevant articles and documents

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand–based drug design

Magalh?es, Joana,Franko, Nina,Annunziato, Giannamaria,Welch, Martin,Dolan, Stephen K.,Bruno, Agostino,Mozzarelli, Andrea,Armao, Stefano,Jirgensons, Aigars,Pieroni, Marco,Costantino, Gabriele,Campanini, Barbara

, p. 1444 - 1452 (2018/09/25)

Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in antibiotic resistance have already been associated with mutations on the genes that codify cysteine biosynthetic enzymes. Therefore, inhibition of cysteine biosynthesis has emerged as a promising strategy to find new potential agents for the treatment of bacterial infection. Following our previous efforts to explore OASS inhibition and to expand and diversify our library, a scaffold hopping approach was carried out, with the aim of identifying a novel fragment for further development. This novel chemical tool, endowed with favourable pharmacological characteristics, was successfully developed, and a preliminary Structure–Activity Relationship investigation was carried out.

Regioselective synthesis of ethyl pyrazolecarboxylates from ethyl 3-[(dimethylamino)methylidene]pyruvate and diethyl 3-[(dimethylamino)methylidene]-2-oxosuccinate. Isolation of ethyl 4,5-dihydro-1-heteroaryl-5-hydroxy-1H-pyrazole-5-carboxylates as stable intermediates in the pyrazole ring formation

Hanzlowsky, Andrej,Jelencic, Blanka,Recnik, Simon,Svete, Jurij,Golobic, Amalija,Stanovnik, Branko

, p. 487 - 498 (2007/10/03)

Reactions of ethyl 3-[(E)-(dimethylamino)methylidene]pyruvate (3) and 3-[(dimethylamino)methylidene]-2-oxosuccinate (4) with hydrazine monohydrochloride (5a) and (hetero)arylhydrazines (5b-i) afforded, regioselectively, 1-substituted ethyl 1H-pyrazole-5-carboxylates 9a-f and diethyl 1H-pyrazole-3,4-dicarboxylates, 11a-i, respectively. Upon treatment of 3 with pyridazinylhydrazines 5d-f, the stable intermediates, 1-substituted ethyl 4,5-dihydro-5-hydroxy-1H-pyrazole-5-carboxylates 8d-f, were isolated. Treatment of compounds 8d-f in acetic acid under reflux furnished the pyrazoles 9d-f. On the other hand, reaction of 3 with N,N′-dimethylhydrazine (5I) gave ethyl 1-methyl-1H-pyrazole-3-carboxylate (14). The structures of compounds 3, 4, 14 were determined by nmr (noesy and hmbc techniques), while the structures of compounds 8f, 9f, and 11e,f were determined by X-ray diffraction.

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