115349-72-9

Upstream product

• 59104-44-8 2-(3-oxo-butyl)malonic acid dimethyl ester 
• 107228-97-7 trans-5-(ethoxycarbonyl)penta-2,4-dien-1-ol 
• 115349-63-8 tert-Butyl-((2E,4E)-6-chloro-hexa-2,4-dienyloxy)-dimethyl-silane 
• 72297-15-5 (2E,4E)-6-((tert-butyldimethylsilyl)oxy)hexa-2,4-dien-1-ol 
• 115349-61-6 ethyl (2E,4E)-6-[(tetrahydro-2H-pyran-2-yl)oxy]hexa-2,4-dienoate 
• 128074-40-8 2-[(2E,4E)-6-(tert-Butyl-dimethyl-silanyloxy)-hexa-2,4-dienyl]-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-malonic acid dimethyl ester 
• 115349-70-7 (Dimethoxy-phosphoryl)-methoxymethoxy-acetic acid methyl ester 
• 115349-69-4 (7E,9E)-5-Benzyloxymethyl-11-(tert-butyl-dimethyl-silanyloxy)-undeca-7,9-dien-2-one 
• 115349-67-2 [(2E,4E)-7-Benzyloxymethyl-9-(2-methyl-[1,3]dioxolan-2-yl)-nona-2,4-dienyloxy]-tert-butyl-dimethyl-silane 
• 115349-65-0 (4E,6E)-8-(tert-Butyl-dimethyl-silanyloxy)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-octa-4,6-dienoic acid methyl ester 
• 115349-66-1 (4E,6E)-8-(tert-Butyl-dimethyl-silanyloxy)-2-[2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl]-octa-4,6-dien-1-ol 
• 115349-68-3 (7E,9E)-5-Benzyloxymethyl-11-hydroxy-undeca-7,9-dien-2-one 
• 20975-32-0 2-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-malonic acid dimethyl ester 
• 83298-18-4 (2E,4E)-ethyl 6-((tert-butyldimethylsilyl)oxy)hexa-2,4-dienoate 

Downstream Products

• 128074-42-0 2-[(2Z,8E,10E)-6-Benzyloxymethyl-12-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trienyl]-malonic acid dimethyl ester 
• 115349-76-3 2-[(2E,8E,10E)-6-Benzyloxymethyl-12-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trienyl]-malonic acid dimethyl ester 
• 115368-96-2 2-((2Z,8E,10E)-6-Benzyloxymethyl-12-hydroxy-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trienyl)-malonic acid dimethyl ester 
• 128074-43-1 2-((2E,8E,10E)-6-Benzyloxymethyl-12-hydroxy-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trienyl)-malonic acid dimethyl ester 
• 115349-75-2 ((2E,4E,10E)-7-Benzyloxymethyl-12-chloro-11-methoxymethoxy-10-methyl-dodeca-2,4,10-trienyloxy)-tert-butyl-dimethyl-silane 
• 128074-41-9 ((2E,4E,10Z)-7-Benzyloxymethyl-12-chloro-11-methoxymethoxy-10-methyl-dodeca-2,4,10-trienyloxy)-tert-butyl-dimethyl-silane 
• 128094-58-6 2-((2E,8E,10E)-6-Benzyloxymethyl-12-chloro-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trienyl)-malonic acid dimethyl ester 
• 115349-73-0 (2Z,8E,10E)-6-Benzyloxymethyl-12-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trien-1-ol 
• 115349-74-1 (2E,8E,10E)-6-Benzyloxymethyl-12-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethoxy-3-methyl-dodeca-2,8,10-trien-1-ol 

Relevant academic research and scientific papers

Synthesis and transannular Diels-Alder reaction of a 13-membered macrocyclic triene having a tetrasubstituted enol ether as dienophile

The syntheses of the acyclic triene trans-trans-cis 27 and trans-trans-trans 31 are described.Macrocyclization and concomitant transannular Diels-Alder reaction were performed with the chloride derivative obtained from the trans-trans-cis triene alcohol 27 yielding a mixture of the tricyclic compounds trans-syn-trans 33 and cis-syn-cis 34.On the other hand, macrocyclization of the chloride derived from trans-trans-trans triene 31 was not successful.

SYNTHESIS AND TRANSANNULAR DIELS-ALDER REACTION OF A 13-MEMBERED MACROCYCLIC TRIENE HAVING A TETRASUBSTITUTED ENOL ETHER AS A DIENOPHILE

Cyclization of TTC allylic chloride 22 gave TTC macrocycle 24 which was directly converted into a mixture of tricycles TST 25 and CSC 26.