115351-30-9

Upstream product

• 140-53-4 p-chlorobenzyl cyanide 
• 77-78-1 dimethyl sulfate 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 115351-44-5 6-chloro-3-cyano-2-methylthio-1-phenylindole 
• 115351-43-4 Acetic acid 1-(4-chloro-phenyl)-1-cyano-2-methylsulfanyl-2-[(Z)-phenylimino]-ethyl ester 
• 115351-45-6 2,3-Bis-(4-chloro-phenyl)-2,3-dicyano-N¹,N⁴-diphenyl-dithiosuccinodiimidic acid dimethyl ester 
• 115351-39-8 Acetic acid 1-cyano-2-methylsulfanyl-2-[(Z)-phenylimino]-1-(3,4,5-trimethoxy-phenyl)-ethyl ester 
• 115351-41-2 2,3-Dicyano-N¹,N⁴-diphenyl-2,3-bis-(3,4,5-trimethoxy-phenyl)-dithiosuccinodiimidic acid dimethyl ester 
• 1178005-81-6 C₂₁H₂₃ClN₆ 
• 101460-15-5 2,6-diamino-4-anilino-5-p-chlorophenylpyrimidine 

Relevant academic research and scientific papers

Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted)aryl-6- [(substituted aryl)amino]pyrimidines

A series of 4-amino-2-(substituted)-5-(substituted)aryl-6-[(substituted) aryl)-amino]pyrimidines was designed based on the triangular pharmacophoric requirements for histamine H1-receptor antagonists. The designed molecules were synthesized by condensation of arylacetonitriles with respective arylisothiocyanates to formcorresponding acrylonitriles followed by cyclocondensation with carboxamidines to afford substituted pyrimidines. All compounds were screened for their histamine H1-receptor antagonistic activity using the model "Inhibition of the isotonic contraction induced by histamine on isolated guinea pig ileum". Target compounds were also evaluated for their sedative potential as well as their anticholinergic activities as these two are known to be the common adverse effects of histamine H1-receptor antagonists. Compounds 2h, 2i, 2j and 2k exhibited potent histamine H1-receptor antagonistic activity, which was found to be comparable with the standard drug, cetirizine (CAS 83881-51-0) and more potent than the conventional drug mepyramine (CAS 91-84-9). Some of the compounds have displayed very low sedative potential compared to diphenhydramine (CAS 58-73-1), but was found higher than cetirizine. None of them showed anticholinergic activity indicating potentialities of this series to be developed as secondgeneration histamine H1-receptor antagonists. ECV Editio Cantor Verlag.

POLARIZED KETENE S,S- AND S,N-ACETALS. PART 52. LEAD TETRA-ACETATE OXIDATION OF 3-ANILINO-3-METHYLTHIO-2-ARYLACRYLONITRILES. A NOVEL APPROACH TO SUBSTITUTED INDOLES

Lead tetra-acetate oxidation of 3-anilino-3-methylthio-2-phenylacrylonitrile (4a) gave the iminoacetate (5a) and 3-cyano-2-methylthio-1-phenylindole (6a).The corresponding methoxy substituted 2-arylacrylonitriles (4b-d), however, yielded the symmetric dim