1153604-76-2Relevant academic research and scientific papers
Toward asymmetric aldol-Tishchenko reactions with enolizable aldehydes: Access to defined configured stereotriads, tetrads, and stereopentads
Rohr, Kerstin,Herre, Robert,Mahrwald, Rainer
supporting information; experimental part, p. 3744 - 3749 (2009/10/02)
(Chemical Equation Presented) Asymmetric aldol-Tishchenko reactions of enolizable aldehydes and ketones in the presence of chiral BINOLTi(OtBu) 2/cinchona alkaloids complexes are described. Different configurative outcomes of these reactions depend on an equilibration through a retro aldol/aldol sequence and can be influenced by the configurative architecture of substrates. The results are explained by means of transition state models and rate constants. These considerations offer a fine-tuning of diastereoselectivity in aldol-Tishchenko reactions. Extensions of this research give access to defined configured stereotriads, stereotetrads, and stereopentads.
