1153685-72-3Relevant academic research and scientific papers
Hammet constants effects in microwave cascade etherification-cyclization- krapcho reaction to access [2,3]-dihydrobenzofuran-3-ones from salicylic derivatives
Farran, Daniel,Bertrand, Philippe
experimental part, p. 989 - 1001 (2012/02/05)
Two methods were evaluated for the synthesis of substituted [2,3]-dihydro-2-methyl-benzofuran-3-ones from corresponding salicylate esters under microwave irradiation. A two-step sequence via ether intermediates was convenient for various substituted salic
Synthesis and modeling of new benzofuranone histone deacetylase inhibitors that stimulate tumor suppressor gene expression
Charrier, Cédric,Clarhaut, Jonathan,Gesson, Jean-Pierre,Estiu, Guillermina,Wiest, Olaf,Roche, Jo?lle,Bertrand, Philippe
supporting information; experimental part, p. 3112 - 3115 (2010/02/28)
New benzofuranones were synthesized and evaluated toward NCI-H661 non-small cell lung cancer cells. Benzamide derivatives possessed micromolar antiproliferative and histone deacetylase inhibitory activities and modulate histone H4 acetylation. Hydroxamic acids were found to be potent nanomolar antiproliferative agents and HDAC inhibitors. Computational analysis presented a rationale for the activities of the hydroxamate derivatives. Impact of the HDAC inhibition on the expression of E-cadherin and the SEMA3F tumor suppressor genes revealed new promising compounds for lung cancer treatments.
