115369-44-3Relevant academic research and scientific papers
Novel efficient preparation method of ceftiofur sulfate intermediate
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Paragraph 0010; 0011l 0012, (2017/08/27)
The invention discloses a novel efficient preparation method of ceftiofur sulfate intermediate. Specifically, the invention relates to a novel efficient preparation method of ceftiofur sulfate intermediate, which relates to a ceftiofur sulfate intermediate shown in formula (II) and the preparation method thereof, the preparation method is short in reaction time and high in yield.
HIGHLY STEREOSELECTIVE METHOXYLATION AT THE SEVEN POSITION OF CEPHALOSPORINS
Tsuji, Teruji,Itani, Hikaru,Ishitobi, Hiroyuki
, p. 2745 - 2746 (2007/10/02)
Addition reaction of methanol to 7-methylsulfeniminocephem 1β-oxide derivatives (6 and 12) under acidic conditions gave exclusively 7β-amino-7α-methoxycephem 1β-oxides (7) stabilized by the formation of an intramolecular hydrogen bond between the 7β-amino and the oxygen atom at the 1-position.
