115369-68-1Relevant academic research and scientific papers
Synthesis and biological evaluation of 2-picolylamide-based diselenides with non-bonded interactions
Rafique, Jamal,Saba, Sumbal,Canto, Rmulo Faria Santos,Frizon, Tiago Elias Allievi,Hassan, Waseem,Waczuk, Emily Pansera,Jan, Maryam,Back, Davi Fernando,Rocha, Joo Batista Teixeira Da,Braga, Antonio Luiz
, p. 10095 - 10109 (2015)
In this paper, we report the synthesis and biological evaluation of picolylamide-based diselenides with the aim of developing a new series of diselenides with O???Se non-bonded interactions. The synthesis of diselenides was performed by a simple and efficient synthetic route. All the products were obtained in good yields and their structures were determined by 1H-NMR, 13C-NMR and HRMS. All these new compounds showed promising activities when tested in different antioxidant assays. These amides exhibited strong thiol peroxidase-like (TPx) activity. In fact one of the compounds showed 4.66 times higher potential than the classical standard i.e., diphenyl diselenide. The same compound significantly inhibited iron (Fe)-induced thiobarbituric acid reactive species (TBARS) production in rat's brain homogenate. In addition, the X-ray structure of the most active compound showed non-bonded interaction between the selenium and the oxygen atom that are in close proximity and may be responsible for the increased antioxidant activity. The present study provides evidence about the possible biochemical influence of nonbonding interactions on organochalcogens potency.
Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and process for the treatment of certain diseases in humans
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, (2008/06/13)
The present invention is related to new diselenobis benzoic acid amides of primary heterocyclic amines of the general formula I STR1 process for producing the same and process for treating certain diseases in human beings by administration of the same to
Diselenobis benzoic acid amides of primary heterocyclic amines, process for producing the same and pharmaceutical compounds comprising the same
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, (2008/06/13)
The present invention is related to new diselenobis benzoic acid amides of primary heterocyclic amines of the general formula I wherein, R1 and R2, which are equal or different from another, represent hydrogen, halogen, C1-4-alkyl, C1-4/s
