1153744-69-4Relevant academic research and scientific papers
Allylic thiocyanates as a new class of antitubercular agents
Silveira, Gustavo P.,Ferreira, Misael,Fernandes, Luciano,Moraski, Garrett C.,Cho, Sanghyun,Hwang, Changhwa,Franzblau, Scott G.,Sa, Marcus M.
supporting information, p. 6486 - 6489 (2012/10/29)
TB is a global public health emergency in which new drugs are desperately needed. Herein we report on the synthesis of a diverse panel of 41 aryl allylic azides, thiocyanates, isothiouronium salts, and N,N′-diacetylisothioureas that were evaluated for their in vitro activity against replicating and non-replicating Mycobacterium tuberculosis (Mtb) H37Rv and toxicity to VERO cells. We found a selective group of new and promising compounds having good (micromolar) to excellent (sub-micromolar) potency against replicating Mtb H37Rv. Allylic thiocyanates bearing halophenyl (halo = 2-Br, 4-Br, 4-Cl, 4-F), 4-methylphenyl and 2-naphthyl moieties were the most active as antitubercular agents. In particular, the 2-bromophenyl-substituted thiocyanate showed MIC = 0.25 μM against replicating Mtb, MIC = 8.0 μM against non-replicating Mtb and IC50 = 32 μM in the VERO cellular toxicity assay.
A new route to allyl thiols and allyl thiocarbamates from Baylis-Hillman adducts
Kim, Young-Gi,Lim, Hee Nam,Lee, Kee-Jung
scheme or table, p. 23 - 27 (2009/04/19)
A facile synthesis of trisubstituted allyl thiols and allyl thiocarbamates has been accomplished from Baylis-Hillman adducts through bromination, thiocyanation, and acid-assisted hydrolysis reaction.
