115378-31-9 Usage
Uses
Used in Pharmaceutical Industry:
(R)-N-BOC-2,2-DIMETHYL-4-VINYLOXAZOLIDINE is used as a reagent in the synthesis of pharmaceuticals for its ability to facilitate the production of complex organic molecules with specific chiral configurations. The BOC protecting group in its structure helps to prevent unwanted reactions, ensuring the desired product is obtained during the synthesis process.
Used in Chemical Industry:
(R)-N-BOC-2,2-DIMETHYL-4-VINYLOXAZOLIDINE is used as a building block in organic synthesis for its versatility in various organic transformations. The vinyloxazolidine group in its structure allows it to participate in cycloadditions and cross-coupling reactions, making it a valuable component in the synthesis of a wide range of organic compounds.
Used in Organic Synthesis:
(R)-N-BOC-2,2-DIMETHYL-4-VINYLOXAZOLIDINE is used as a chiral building block in organic synthesis for its specific three-dimensional arrangement of atoms. This chiral compound can be incorporated into the synthesis of enantioselective products, which are important in various applications, including pharmaceuticals and agrochemicals. The "R" configuration at its chiral center ensures the desired enantiomeric purity is achieved during the synthesis process.
Check Digit Verification of cas no
The CAS Registry Mumber 115378-31-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,3,7 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 115378-31:
(8*1)+(7*1)+(6*5)+(5*3)+(4*7)+(3*8)+(2*3)+(1*1)=119
119 % 10 = 9
So 115378-31-9 is a valid CAS Registry Number.
115378-31-9Relevant academic research and scientific papers
Methylenation of aldehydes: Transition metal catalyzed formation of salt-free phosphorus ylides
Lebel, Heandleandne,Paquet, Valeandrie,Proulx, Caroline
, p. 2887 - 2890 (2007/10/03)
A variety of terminal alkenes are produced in excellent yields by the rhodium(I)-catalyzed methylenation of aldehydes using TMSCHN2 and PPh3 [Eq. (1)]. These mild reaction conditions allowed the conversion of enolizable substrates and the chemoselective methylenation of aldehydes over ketones. TMS = trimethylsilyl.
Synthesis of Chiral Vinylglycines
Beaulieu, Pierre L.,Duceppe, Jean-Simon,Johnson, Carolyne
, p. 4196 - 4204 (2007/10/02)
(R)- or (S)-benzyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (7a) and (R)- or (S)-1,1-dimethylethyl 4-formyl-2,2-dimethyl-3-oxazolidinecarboxylate (7b), readily available from serine, react with Wittig reagents to give alkenes 8.Selective deprotection followed by oxidation of the resulting unsaturated amino alcohols 9 provides vinylglycines 5 of defined configuration (>95percent ee) and double-bond geometry.D-Vinylglycines are obtained from L-serine, and conversely, D-serine gives β,γ-unsaturated amino acids with the L configuration.The double-bond geometry is controlled by the nature of the phosphorous ylide employed.The scope and limitations of this new methodology for the preparation of chiral vinylglycines is examined.
