1153891-18-9Relevant academic research and scientific papers
Facile reaction of thiols and amines with alkyl 4-hydroxy-2-alkynoates in water under neutral conditions and ultrasound irradiation
Arcadi, Antonio,Alfonsi, Maria,Marinelli, Fabio
experimental part, p. 2060 - 2064 (2009/09/05)
This Letter describes an alternative protocol for the Michael addition of thiols to 4-hydroxy-2-alkynoates. The reaction proceeds at room temperature in water under ultrasound irradiation. With amines instead of thiols a sequential conjugate addition/lact
