115393-64-1

Basic information

• Product Name: 9H-purin-6-amine, 2-butyl-9-methyl-
• Synonyms: 2-Butyl-9-methyl-9H-purin-6-amine
• CAS NO: 115393-64-1
• Molecular Formula: C₁₀H₁₅N₅
• Molecular Weight: 205.2596
• Mol File: 115393-64-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 323.515°C at 760 mmHg
• Flash Point: 149.457°C
• Density: 1.311g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.666
• CAS DataBase Reference: 9H-purin-6-amine, 2-butyl-9-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-purin-6-amine, 2-butyl-9-methyl-(115393-64-1)
• EPA Substance Registry System: 9H-purin-6-amine, 2-butyl-9-methyl-(115393-64-1)

Safety Data

• Hazardous Substances Data: 115393-64-1(Hazardous Substances Data)

Upstream product

• 1235863-00-9 2-n-butyl-6-chloro-9-methyl-9H-purine 

Relevant articles and documents

Direct B-alkyl suzuki-miyaura cross-coupling of 2-halopurines. Practical synthesis of ST1535, a potent adenosine A2A receptor antagonist

(Figure presented) The scope and limitations of using palladium-catalyzed cross-coupling reactions of diverse butyl metal species with two different 2-halopurines were evaluated. While tributylboranes reacted readily and regioselectively with both 2-chloro-6-dibenzylaminopurines and 2-iodo-6-chloropurines, all the other alkyl metal species were much less reactive and gave very poor yield and/or selectivity of the desired product. This protocol was applied to the synthesis of an important adenosine A 2A receptor antagonist, ST1535.