1154-46-7

Upstream product

• 85-44-9 phthalic anhydride 
• 929-17-9 7-aminoheptanoic acid 

Downstream Products

• 103033-63-2 2-(4-diethylamino-phenylimino)-3-oxo-9-phthalimido-nonanenitrile 
• 102952-16-9 2-(4-dimethylamino-phenylimino)-3-oxo-9-phthalimido-nonanenitrile 
• 138349-43-6 7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-heptanoic acid [5-methoxy-3-methyl-1-(4-nitro-phenyl)-1H-indol-2-yl]-amide 
• 138349-45-8 7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-heptanoic acid [3-methyl-1-(4-nitro-phenyl)-1H-indol-2-yl]-amide 
• 138349-48-1 7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-heptanoic acid (3-isopropyl-1-phenyl-1H-indol-2-yl)-amide 
• 138349-47-0 7-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-heptanoic acid (3-ethyl-1-phenyl-1H-indol-2-yl)-amide 
• 138349-42-5 3-methyl-1-phenyl-2-(7-phthalimidoheptanoyl)aminoindole 

Relevant academic research and scientific papers

Synthesis and antiherpetic activity of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine

[Figure not available: see fulltext.] A method for the synthesis of novel purine conjugates with 7,8-difluoro-3-methyl-3,4-dihydro-2H-1,4-benzoxazine containing fragments of ω-amino acids with different lengths of the polymethylene chain as a linker has been developed. It was found in experiments in vitro that the obtained compounds are active against the herpes simplex virus type 1, including the acyclovir-resistant strain.

Assembling of medium/long chain-based β-arylated unnatural amino acid derivatives via the Pd(II)-catalyzed sp3 β-C-H arylation and a short route for rolipram-type derivatives

In this paper, we report the assembling of libraries of β-arylated short/medium/long chain-based non-α-amino acid (aminoalkanoic acid) derivatives via the Pd(II)-catalyzed, bidentate directing group 8-aminoquinoline-aided sp3 β-C-H activation/arylation method. Short/medium chain-based unnatural amino acid derivatives containing an aryl group at the β-position are promising small molecules with therapeutic properties. Thus, it is necessary to enrich the libraries of short/medium/long chain-based unnatural amino acid derivatives containing an aryl group at the β-position. Considering the importance of β-arylated short/medium/long chain-based non-α-amino acid derivatives, an inclusive attention was paid to explore the Pd(II)-catalyzed sp3 β-C-H arylation of short/medium/long chain-based non-α-amino acids. Representative synthetic transformations including a short route for the assembling of rolipram and related compounds and 3-arylated GABA derivatives such as, baclofen, phenibut and tolibut were shown using selected β-C-H arylated non-α-amino acid derivatives.

GUANIDINO IMIDAZOLES AND THIAZOLES

The invention relates to guanidine derivatives of imidazoles and thiazoles which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture, to pharmaceutical compositions containing them and to methods of using such guanidine derivatives and compositions. The guanidine derivatives are of the general formula I: STR1 in which X is S or NH, Y is CH 2, a direct bond or a vinylene radical, m is 0 to 4 and n is 1 to 4, R 1 is hydrogen, halogen or alkyl, R 2 is hydrogen, alkyl, alkanoyl or aroyl, A is a 3,4-dioxocyclobuten-1,2-diyl radical or C=Z in which Z is O, S, NCN, NNO 2, CHNO 2, NCONH 2, C(CN) 2, NCOR 3, NCO 2 R 3, NSO 2 R 3 or NR 4 in which R 3 is alkyl or aryl and R 4 is hydrogen or alkyl, B is alkoxy or alkylthio or NR 5 R 6 in which R 5 and R 6 are independently hydrogen, alkyl, alkenyl, cycloalkyl, hydroxyalkyl, alkoxyalkyl, alkylaminoalkyl or dialkylaminoalkyl; and the salts thereof.