115416-38-1

Basic information

• Product Name: 5-(Biotinamido)pentylamine
• Synonyms: Biotinyl cadaverine;1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(5-aminopentyl)hexahydro-2-oxo-, (3as-(3aalpha,4beta,6aalpha))-;1H-Thieno(3,4-D)imidazole-4-pentanamide, N-(5-aminopentyl)hexahydro-2-oxo-, (3as,4S,6ar)-;(3aS,4S,6aR)-N-(5-AMinopentyl)hexahydro-2-oxo-thieno[3,4-d]iMidazole-4-pentanaMide;Cadaverine-X-biotin
• CAS NO: 115416-38-1
• Molecular Formula: C₁₅H₂₈N₄O₂S
• Molecular Weight: 328.47
• Product Categories: Biotin Derivatives;Chiral Compounds;Intermediates;biotinyl
• Mol File: 115416-38-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 652°Cat760mmHg
• Flash Point: 348.1°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 7.01E-17mmHg at 25°C
• Refractive Index: 1.529
• PKA: 13.90±0.40(Predicted)
• CAS DataBase Reference: 5-(Biotinamido)pentylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(Biotinamido)pentylamine(115416-38-1)
• EPA Substance Registry System: 5-(Biotinamido)pentylamine(115416-38-1)

Safety Data

• Hazardous Substances Data: 115416-38-1(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

Different sources of media describe the Uses of 115416-38-1 differently. You can refer to the following data:
1. Reagent used in the preparation of a variety of biotin derivatives.
2. Iodoacetyl LC biotin, amine and sulfhydryl reactive biotinylation reagent

InChI:InChI=1/C15H28N4O2S/c16-8-4-1-5-9-17-13(20)7-3-2-6-12-14-11(10-22-12)18-15(21)19-14/h11-12,14H,1-10,16H2,(H,17,20)(H2,18,19,21)/t11-,12-,14-/m0/s1

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 148759-41-5 1-azido-5-aminopentane 
• 58-85-5 biotin 
• 17607-21-5 1,5-diazidopentane 
• 462-94-2 1,5-diaminopentane 
• 35013-72-0 biotin N-Hydroxysuccinimide ester 
• 51644-96-3 5-tert-butoxycarbonylamino-1-aminopentane 
• 328273-17-2 (3aS,4S,6aR)-N-[5-[(1,1-dimethylethoxy)carbonyl]aminopentyl]hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide 

Downstream Products

• 1417160-79-2 C₅₅H₇₅N₁₁O₈S 
• 1133960-28-7 C₆₁H₈₁N₇O₉S 
• 893422-03-2 [(6S,7R)-8-oxo-9-({5-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-pentylcarbamoyl}-methyl)-6-phenyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-carbamic acid tert-butyl ester 
• 893421-93-7 [(6R,7S)-8-oxo-9-({5-[5-((3aR,6S,6aS)-2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-pentylcarbamoyl}-methyl)-6-phenyl-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-carbamic acid tert-butyl ester 
• 359766-88-4 C₂₆H₃₉N₅O₄S 
• 794525-93-2 {5-(4-benzoyl-phenyl)-1-benzyl-2-(tert-butyl-dimethyl-silanyloxy)-4-[3-methyl-1-(1-{5-[5-(2-oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-butylcarbamoyl]-pentyl}-carbamic acid tert-butyl ester 
• 259270-28-5 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide 

Relevant articles and documents

Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin

Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based on combination principles by merging the structures of β-lactams and purine-type compounds known as tubulin polymerization inhibitor and katanin activity up-regulator, respectively. Their antitumor activities were evaluated in vitro and the mechanism was elucidated, leading to the identification of 1,6-diaryl-1H-imidazo[4,5-c]pyridin-2(3H)-one 20b as the first bifunctional agent that can target both tubulin and katanin simultaneously. The in vivo assays verified that compound 20b significantly inhibited xenograft tumor growth with good pharmacokinetic characteristics, demonstrating a promising potential for further development into anti-tumor drug candidates with a unique mechanism of dual-targeting microtubule.

PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS

Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions.

NOVEL MOLECULAR PROBES

The present invention relates to novel molecular probes having the formula (I) (I) useful for the characterization, detection, localization and isolation of the γ-secretase enzyme.