1154426-25-1Relevant articles and documents
Atropisomeric small molecule Bcl-2 ligands: Determination of bioactive conformation
Porter, John,Payne, Andrew,Whitcombe, Ian,de Candole, Ben,Ford, Daniel,Garlish, Rachel,Hold, Adam,Hutchinson, Brian,Trevitt, Graham,Turner, James,Edwards, Chloe,Watkins, Clare,Davis, Jeremy,Stubberfield, Colin
scheme or table, p. 1767 - 1772 (2009/12/01)
The separation of atropisomeric conformers of 1,2,3,4-tetrahydroisoquinoline amide Bcl-2 ligands allowed the identification of the bioactive conformer which was subsequently confirmed by X-ray crystallography.