115444-73-0 Usage
General Description
4-(2-methyl-1H-benzimidazol-1-yl)butanoic acid, also known as PPI-2458, is a chemical compound that belongs to the class of benzimidazole derivatives. It is a potent and selective histamine H2 receptor antagonist, and has been studied for its potential use in the treatment of gastric and duodenal ulcers, gastroesophageal reflux disease, and other related conditions. The compound works by blocking the action of histamine at the H2 receptors in the stomach, which reduces the production of stomach acid and helps to heal ulcers and relieve symptoms of acid reflux. Research on PPI-2458 is ongoing, and it has shown promise as a potential therapeutic agent in gastrointestinal disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 115444-73-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,4,4 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115444-73:
(8*1)+(7*1)+(6*5)+(5*4)+(4*4)+(3*4)+(2*7)+(1*3)=110
110 % 10 = 0
So 115444-73-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O2/c1-9-13-10-5-2-3-6-11(10)14(9)8-4-7-12(15)16/h2-3,5-6H,4,7-8H2,1H3,(H,15,16)
115444-73-0Relevant articles and documents
Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors
Chen, Chen,Yang, Xinying,Fang, Hao,Hou
, (2019/08/13)
Matrix metalloproteinases (MMPs) play important roles in many diseases including cancer. With moderate metal-binding affinity, 8-hydroxyquinoline has gained much interest in current drug design and development. Specially, it has been reported that 8-hydroxyquinoline derivatives serve as MMP-2 inhibitors with micromolar IC50 values. In the current study, a series of 8-hydroxyquinoline derivatives were designed and synthesized as new MMP-2 and MMP-9 inhibitors. The most active compounds 5e and 5h not only displayed good inhibitory activities against MMP-2/9 with IC50 at submicromolar level, but also possessed potent anti-proliferative, anti-invasive and anti-angiogenesis activity in A549 cell line. Western blot also revealed that 5e and 5h down-regulate the expression of MMP-2 and MMP-9 in A549 cell line. Moreover, flow cytometry analysis indicated that compound 5e could promote apoptosis of A549 cells in vitro. Molecular docking analysis also revealed favorable binding modes of 5e in the active sites of MMP-2 and MMP-9.
