1154585-25-7Relevant academic research and scientific papers
Diastereoselective synthesis of complex cis-hexahydroindanes by reductive alkylation
Kaplan, Hilan Z.,Rendina, Victor L.,Kingsbury, Jason S.
, p. 4620 - 4626 (2013)
An efficient and operationally simple approach to complex cis-hexahydroindanes is reported. Upon Birch reduction of unprotected, C4-alkylated tetrahydroindanols and electrophilic trapping of the tetrasubstituted enolate, cis-fused products are formed with a new stereogenic quaternary carbon. The reaction is convergent, completely diastereoselective, and shows a broad scope with regard to the electrophile.
