1154737-84-4Relevant academic research and scientific papers
Cobalt-Catalyzed Remote Hydroboration of Alkenyl Amines
Lei, Yaqin,Huang, Jiaxin,Zhao, Wanxiang
supporting information, p. 7797 - 7802 (2021/10/20)
We here present a generally applicable cobalt-catalyzed remote hydroboration of alkenyl amines, providing a practical strategy for the preparation of borylamines and aminoalcohols. This method shows broad substrate scope and good functional group tolerance, tolerating a series of alkenyl amines, including alkyl-alkyl amines, alkyl-aryl amines, aryl-aryl amines, and amides. Of note, this protocol is also compatible with a variety of natural products and drug derivatives. Preliminary mechanistic studies suggest that this transformation involves an iterative chain walking and hydroboration sequence.
Amination of allylic alcohols in water at room temperature
Nishikata, Takashi,Lipshutz, Bruce H.
supporting information; experimental part, p. 2377 - 2379 (2009/12/01)
The "trick" to carrying out regiocontrolled aminations of allylic alcohols in water as the only medium is use of a nanomicelle's interior as the organic reaction solvent. When HCO2Me is present, along with the proper base and source of catalytic Pd, allylic amines are cleanly formed at room temperature.
