1154750-85-2Relevant academic research and scientific papers
A comparative study using conventional methods, ionic liquids, microwave irradiation and combinations thereof for the synthesis of 5-trifluoroacetyl-1,2,3,4-tetrahydropyridines
Andrade, Valquiria P.,Mittersteiner, Mateus,Lobo, Márcio M.,Frizzo, Clarissa P.,Bonacorso, Hélio G.,Martins, Marcos A.P.,Zanatta, Nilo
supporting information, p. 891 - 894 (2018/02/14)
This study reports a comparison between conventional methods, ionic liquids, microwave (MW) irradiation, and combinations thereof for the synthesis of a series of fourteen 1-aryl-2-arylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines. In all of the reactions tested, the products were obtained at very good yields (87–97%), but the reaction times were very different, depending on the method used. Comparing to other methods, the time decreased to 1 min when [BMIM]BF4 under MW irradiation was used, thus evidencing a synergic effect.
Highly chemoselective synthesis of 6-Alkoxy-l-aIkyl(aryl)-3- trifluoroaeetyl-1,4,5,6 tetrahydropyridlines and 1-Alkyl(aryl)-6-anino-3- trifluoroacetyl-1,4,5,6-tetrahydropyridines
Zanatta, Nilo,Fernandes, Liana Da S.,Naehtigall, Fabiane M.,Coelho, Helena S.,Aniaral, Simone S.,Flores, Alex F. C.,Bonacorso, Helio G.,Martins, Marcos A. P.
experimental part, p. 1435 - 1444 (2009/08/07)
A simple and highly chemoselective method for the synthesis of a large series of novel 6-alkoxy-1-alkyl (aryl)-3-trifluoro-acetyl-1,4,5,6- tetrahydropyridines and l-alkyl(aryl)-6-amino-3-trifluoroacetyl-l,4,5,6- tetrahydropyridines, from the reaction of 6
