115481-99-7Relevant articles and documents
N-METHYL AMINO ACIDS
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Page 41, (2010/02/06)
The present invention relates to a compound of formula (I) or (II), processes for preparing them, peptides including them and kits involving them.
An efficient synthesis of N-methyl amino acids by way of intermediate 5-oxazolidinones
Aurelio, Luigi,Box, John S.,Brownlee, Robert T. C.,Hughes, Andrew B.,Sleebs, Marianne M.
, p. 2652 - 2667 (2007/10/03)
N-Methyl amino acids occur in many natural products. Experimental strategies are presented for a unified approach to the synthesis of N-methyl derivatives through 5-oxazolidinones of the 20 common L-amino acids. The amino acids with reactive side chains that required protecting groups or devoted syntheses for side chain construction for N-methylation to proceed included serine, threonine, tyrosine, cysteine, methionine, tryptophan, asparagine, histidine, and arginine. The studies have provided improved methods for the preparation of N-methyl serine, threonine, and tyrosine. All 20 of the common L-amino acids are now available in suitable forms for solid or solution-phase peptide synthesis.
A simple and rapid protocol for N-methyl-α-amino acids
Reddy, G. Vidyasagar,Iyengar
, p. 299 - 300 (2007/10/03)
A two step strategy for optically pure N-Protected-N-methyl-α-amino acids starting from N-protected-α-amino acids via reductive cleavage of oxazolidinones using NaCNBH3/TMSCl is described.
