1154881-57-8

Basic information

• Product Name: 1-(4-Fluorobenzyl)-1H-pyrazole-4-carboxylic acid
• Synonyms: 1-(4-Fluorobenzyl)-1H-pyrazole-4-carboxylic acid;1H-Pyrazole-4-carboxylic acid, 1-[(4-fluorophenyl)methyl]-
• CAS NO: 1154881-57-8
• Molecular Formula: C₁₁H₉FN₂O₂
• Molecular Weight: 220.2
• Mol File: 1154881-57-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 430.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 3.83±0.10(Predicted)
• CAS DataBase Reference: 1-(4-Fluorobenzyl)-1H-pyrazole-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorobenzyl)-1H-pyrazole-4-carboxylic acid(1154881-57-8)
• EPA Substance Registry System: 1-(4-Fluorobenzyl)-1H-pyrazole-4-carboxylic acid(1154881-57-8)

Safety Data

• Hazardous Substances Data: 1154881-57-8(Hazardous Substances Data)

Usage

General Description

1-(4-fluorobenzyl)-1H-pyrazole-4-carboxylic acid is a chemical compound with the molecular formula C11H8FN3O2. It is a derivative of pyrazole, a five-membered aromatic heterocycle that contains two nitrogen atoms. The compound contains a fluorobenzene group attached to the pyrazole core, as well as a carboxylic acid group. It has potential applications in pharmaceutical and medicinal chemistry, as similar compounds have been studied for their potential as anti-inflammatory and analgesic agents. The presence of the fluorobenzene group may also impart unique chemical and pharmacological properties to the compound.

Upstream product

• 1094202-69-3 ethyl 1-(4-fluorobenzyl)-1H-pyrazole-4-carboxylate 
• 459-46-1 4-Fluorobenzyl bromide 
• 37622-90-5 4-ethoxycarbonylpyrazole 

Downstream Products

• 1449321-50-9 [(R)-1-(3-{[1-(4-fluorobenzyl)-1H-pyrazole-4-carbonyl]amino}-5-methoxy-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-yl]carbamic acid tert-butyl ester 
• 1449321-10-1 1-(4-fluorobenzyl)-1H-pyrazol-4-carboxylic acid (5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)amide 
• 1449321-49-6 1-(4-fluorobenzyl)-1H-pyrazol-4-carboxylic acid [4-((R)-3-aminopiperidin-1-yl)-5-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 
• 1245907-95-2 C₁₁H₈ClFN₂O 
• 1449321-60-1 [(R)-1-(3-{[1-(4-fluorobenzyl)-1H-pyrazol-4-carbonyl]amino}-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-piperidin-3-yl]carbamic acid tert-butyl ester 
• 1449321-57-6 1-(4-fluorobenzyl)-1H-pyrazol-4-carboxylic acid [4-((R)-3-aminopiperidin-1-yl)-5-trifluoromethyl-1H-pyrrolo[2,3-b]pyridin-3-yl]amide 

Relevant articles and documents

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

INDOLYL- PYRIDONE DERIVATIVES HAVING CHECKPOINT KINASE 1 INHIBITORY ACTIVITY

Compounds of formula (I) have checkpoint kinase 1 (CHK1 ) inhibitory activity: wherein R1, R2, R5 and R6 are independently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxymethyl, methoxy, triflu