115499-22-4Relevant academic research and scientific papers
Synthesis and Antitumor Activity of 5-Deaza-5,6,7,8-tetrahydrofolic Acid and Its N10-Substituted Analogues
Taylor, Edward C.,Hamby, James M.,Shih, Chuan,Grindey, Gerald B.,Rinzel, Sharon M.,et al.
, p. 1517 - 1522 (2007/10/02)
Syntheses of 5-deaza-5,6,7,8-tetrahydrofolic acid (7a) and its 10-formyl (7b), 10-acetyl (7c), and 10-methyl (7d) derivatives are described.These compounds, prepared as analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid (DDATHF), the lead compound of
