1155089-38-5Relevant academic research and scientific papers
Copper-catalyzed C–N cross-coupling of arylboronic acids with N-acylpyrazoles
Zhang, Jin,Jia, Run-Ping,Wang, Dong-Hui
, p. 3604 - 3607 (2016/07/21)
A copper-catalyzed C–N bond forming reaction of arylboronic acids and N-acylpyrazoles was developed. This procedure used N-acetyl protected pyrazoles as starting material instead of free pyrazoles (NH). The reaction worked under neutral conditions and did not require any base or ligand. The reaction showed good functional group tolerance.
Iron complex-catalyzed N-arylation of pyrazoles under aqueous medium
Lee, Hang Wai,Chan, Albert S.C.,Kwong, Fuk Yee
experimental part, p. 5868 - 5871 (2010/01/11)
Commercially available FeCl3·6H2O with conformationally rigid diamine ligand is a highly effective catalyst for N-arylation of pyrazoles using aryl and heteroaryl iodides. It is notable to show that this complex is tolerable under aqueous medium and particularly the whole reaction utilizes water as the sole solvent without any additional organic co-solvents and surfactants. Attempted study using other nitrogen nucleophiles is described. This newly developed system provides an alternative protocol to Cu- and Pd-catalyzed N-arylation reactions.
