115522-40-2

Upstream product

• 16801-70-0 N-cycloheptyl-4-methylbenzenesulfonamide 
• 97399-15-0 Acetic acid (1S,4R)-4-(toluene-4-sulfonylamino)-cyclohept-2-enyl ester 
• 97399-15-0 Acetic acid (1R,4R)-4-(toluene-4-sulfonylamino)-cyclohept-2-enyl ester 
• 115522-48-0 Acetic acid (1S,4R)-4-(toluene-4-sulfonylamino)-cycloheptyl ester 
• 115522-48-0 Acetic acid (1R,4R)-4-(toluene-4-sulfonylamino)-cycloheptyl ester 
• 115522-50-4 N-((1R,4S)-4-Hydroxy-cycloheptyl)-4-methyl-benzenesulfonamide 
• 115522-50-4 N-((1R,4R)-4-Hydroxy-cycloheptyl)-4-methyl-benzenesulfonamide 
• 115522-56-0 N-((1R,4R)-4-Chloro-cycloheptyl)-4-methyl-benzenesulfonamide 
• 82736-40-1 (Z)-1-acetoxy-4-chlorocyclohept-2-ene 
• 876938-53-3 Cyclohepta-1,3-diene 
• 115522-54-8 Methanesulfonic acid (1R,4R)-4-(toluene-4-sulfonylamino)-cycloheptyl ester 

Relevant academic research and scientific papers

Synthesis of Bridged Bicyclic Amines by Intramolecular Amination of Remote C-H Bonds: Synergistic Activation by Light and Heat

The construction of complex aza-cycles is of interest to drug discovery due to the prevalence of nitrogen-containing heterocycles in pharmaceutical agents. Herein we report an intramolecular C-H amination approach to afford value-added and complexity-enriched bridged bicyclic amines. Guided by density functional theory and nuclear magnetic resonance investigations, we determined the unique roles of light and heat activation in the bicyclization mechanism. We applied both light and heat activation in a synergistic fashion, achieving gram-scale bridged aza-cycle synthesis.

STEREOCONTROLLED SYNTHESIS OF TROPANOL DERIVATIVES VIA PALLADIUM-CATALYZED REACTIONS

A general method for the transformation of 1,3-cycloheptadienes to tropane alkaloid derivatives was developed.The procedure was applied to the stereocontrolled synthesis of the exo- and endo-tropanol derivatives 1 and 2.The approach is based on a dual stereocontrol in the 1,4-functionalization of conjugated dienes.